Overview

Why use probiotics for yeast-balance?†

Because yeast thrives in the intestines

Fast food, stress and exposure to toxins, plus overly acidic pH levels can leave you vulnerable to yeast. Maintaining an optimal yeast balance with the right probiotics can help you stay much more comfortable.†

Why use Pearls YB?

It provides triple-strength protection for your ultimate comfort

Pearls YB contains three types of Lactobacillus - clinically shown to create an intestinal environment that supports healthy yeast balance.† That means comfort for you, as Pearls YB supports vaginal and urinary tract health.†

Directions

One capsule daily, with water or your favorite beverage. May be taken with or without food. Do not chew or crush.

Pill Size

Interactions and Depletions

Technical Data

Description

Pearls YB yeast-balancing probiotics is a unique dietary supplement designed to build a healthier gastrointestinal environment by promoting healthy microflora balance.^† The formula includes three Lactobacillus species, which have been shown to restore yeast balance in clinical and laboratory settings.^† Pearls YB can be used everyday or episodically and is safe for pregnant women.

While many probiotic products are unstable at room temperature and fail to meet their label claim in less than 12 months after manufacture, Pearls YB utilizes an advanced encapsulation technique, known as True Delivery^™ Technology, which ensures the product is stable at room temperature for up to 18 months.^† Additionally, the unique coating protects the probiotic bacteria from harsh stomach acid so they can be released live and intact in the intestines, where they need to thrive to perform their beneficial function.^†

Pearls YB:

• Powerful: Three well studied probiotic species shown to support optimal yeast balance^†
• Protected: Patented True Delivery Technology safeguards probiotics from harsh stomach acid and safely releases them in the intestines for greatest benefits^†
• Preserved: Guaranteed to deliver live, intact probiotics throughout product shelf-life, not just “at time of manufacture”
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Introduction


Yeasts are eukaryotic microorganisms classified as fungi. They are often found in the human mouth, throat, large intestine, and vaginal tract. Yeasts grow in warm, moist environments, such as in mucous membranes and folds of tissue. Because the intestinal and vaginal tracts can be vulnerable to pH changes, maintaining healthy pH balance is an important factor in restoring yeast and microflora balance.^†1



How Does It Work?


Pearls YB^™ yeast-balancing probiotics combines three of the best studied probiotic species shown to promote yeast balance.^† Probiotics, such as Lactobacillus acidophilus, Lactobacillus rhamnosus, and Lactobacillus plantarum, are live microbial food supplements that are non-toxic and do not cause disease (non-pathogenic). Because probiotics do not permanently colonize in the body, they must be ingested regularly for their health-promoting effects to persist.^† After ingestion, probiotics must adhere to the wall of the intestine or the vagina. Once attached, the bacteria are capable of multiplying and colonizing, thereby enhancing optimal microflora balance.^†

The following chart summarizes the yeast balancing benefits of the probiotic species found in Pearls YB.^†

Probiotic	Benefit
L. acidophilus	Lactobacillus is a predominant genus found in the urogenital tract. The ability of Lactobacillus to attach to the cells lining the vagina and its ability to promote a healthy pH are critical to maintaining healthy yeast balance.†2,3 Lactobacillus acidophilus is one of the best studied probiotic species. It's ability to adhere to vaginal epithelial cells and colonize has been documented.†3,4 In multiple clinical studies, L. acidophilus has been shown to support healthy yeast balance.†5-7 In fact, one year-long clinical trial found that ingestion of an L. acidophilus supplemented yogurt yielded a 3-fold advantage in maintaining healthy yeast balance versus placebo.†7 Additionally, L. acidophilus has been shown to support healthy yeast balance in the oral cavity (mouth) in an animal model study.†8
L. rhamnosus	In a cell study comparing 34 Lactobacillus strains, L. rhamnosus was found to be the most effective in attaching to uroepithelial cells and supporting healthy microflora balance.†2 Adding L. rhamnosus and another probiotic culture to cheese has been clinically shown to enhance yeast balance.† The 16-week, randomized, double-blind, placebo-controlled clinical trial included 276 elderly people and found that those who consumed the probiotic experienced a 75 percent improvement in maintaining healthy yeast balance.†9 The benefits of L. rhamnosus on yeast balance in infants has also been studied.†10
L. plantarum	Lactobacillus plantarum is another species which has been shown to support healthy yeast balance in a number of cell studies.† Additionally, L. plantarum has been shown to promote a healthy balance of a broad-spectrum of fungal organisms.†11-14

True Delivery ™ Technology
Our laboratory tested leading probiotic nutritional supplements in the marketplace. These supplements were best selling brands, two of the supplements were enteric coated, and all had label guarantees about potency (guaranteed number of live bacteria). The laboratory scientists counted the number of living bacteria found and compared these findings to the bacterial levels claimed by each manufacturer. The products were also subjected to a simulation of stomach acid conditions, after which the levels of living bacteria were re-counted.

The laboratory results found that 50 percent of the probiotic supplements contained less than the number of living bacteria that they claimed on their labels. Furthermore, the laboratory results found that 75 percent of the supplements had less than 15 percent of the living bacteria claimed on the manufacturer's label survive the simulated stomach conditions.¹⁵

Pearls YB yeast-balancing probiotics^† uses a revolutionary proprietary “pearl” encapsulation process called True Delivery Technology. The True Delivery Technology is a special type of natural coating that protects the probiotic bacteria from stomach acid.^†

The patented seamless pearl capsule of Pearls YB assures that virtually all the bacteria remain uninjured and healthy to colonize in the intestine.^†15 In addition, the special pearl capsule's ability to seal the bacteria inside it eliminates the need for the nutritional supplement to be refrigerated – though they can be kept in the refrigerator, if desired.^†

Microbial Growth: The Importance of True Delivery^™ Technology
Laboratory research has shown that microbial growth follows a relatively set pattern. After microorganisms adjust to a new environment, the bacteria enter an exponential growth phase, where maximum growth and division occurs. During this phase, live and active bacteria will replicate about every 20 minutes. Within 2 hours, 1 billion healthy, live bacteria cultures will yield approximately 64 billion bacteria (see Table 1).¹⁶

Evidence suggests that supplementation with protected probiotics supplements is critical to maintaining healthy bacterial growth and microflora balance in the intestines.^† Pearls YB^™ uses patented True Delivery Technology, guaranteed to deliver live and active bacteria to the intestines.^†15,17 Because of the potential for fast growth, it is not the absolute number of probiotics listed on the label that is important. Rather, it is the method of delivery and the quality of bacteria that reach the small intestine that matters. Once released, healthy, viable probiotics can quickly colonize and exert benefits.^†

Table 1: Microbial Growth


Time (min)	Count (cultures)
0	1 billion
20	2 billion
40	4 billion
60	8 billion
80	16 billion
100	32 billion
120	64 billion

Conclusion
Pearls YB yeast-balancing probiotics is a daily supplement designed to build a healthy intestinal environment and promote yeast balance.^† The formula contains three of the best studied strains for vaginal health.^†



Recommendations


One capsule daily, with water or your favorite beverage. May be taken with or without food. Do not chew or crush.



Precautions


If taking prescription drugs, consult your healthcare practitioner prior to use.



How Is It Supplied?



• 04213; 30 capsules




Storage Recommendations


Store at controlled room temperature, 59° to 86°F (15° – 30°C).



References



1. Bunner LS, Suddarth DS. Management of Patients with Gynecologic Disorders. In: Textbook of Medical-Surgical Nursing, 6th edition. Philadelphia, PA: J.B.Lippencott Company; 1988: 1102-5.
2. Reid G. Probiotic agents to protect the urogenital tract against infection. Am J Clin Nutr. 2001 Feb;73(2):437S-443S.
3. Wagner RD, Pierson C, Warner T, et al. Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficient mice. Infection and Immunity. 1997 Oct;4165-72.
4. Boris S, Suarez JE, Vazquez F, Barbes C. Adherence of human vaginal lactobacillus to vaginal epithelial cells and interaction with uropathogens. Infect Immun. 1998 May;66(5):1985-9.
5. Williams AB, Yu C, Tashima K, Burgess J, Danvers K. Evaluation of two self-care treatments for prevention of vaginal candidiasis in women with HIV. J Assoc Nurses AIDS Care. 2001 Jul-Aug;12(4):51-7.
6. Shalev E, Battino S, Weiner E, Colodner R, Keness Y. Ingestion of yogurt containing Lactobacillus acidophilus compared with pasteurized yogurt as prophylaxis for recurrent candidal vaginitis and bacterial vaginosis. Arch Fam Med. 1996 Nov-Dec;5(10):593-6.
7. Hilton E, Isenberg HD, Alperstein P, France K, Borenstein MT. Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis. Ann Intern Med. 1992 Mar;116(5):353-7.
8. Elahi S, Pang G, Ashman, and Clancy R. Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus. Clin Experi Immunol. 2005;141:29-36.
9. Hatakka K, Ahola AJ, Yli-Knuuttila H, Richardson M, et al. Probiotics reduce the prevalence of oral candida in the elderly – a randomized controlled trial. J Dent Res. 2007 Feb;86(2):125-30.
10. Manzoni P, Mostert M, Leonessa ML, et al. Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clin Infect Dis. 2006 Jun 15;42(12):1735-42.
11. Wynne AG, McCartney AL, Brostoff J, Hudspith BN, Gibson GR. An in vitro assessment of the effects of broad-spectrum antibiotics on the human gut microflora and concomitant isolation of a Lactobacillus plantarum with anti-Candida activities. Anaerobe. 2004 Jun;10(3):165-9.
12. Payne S, Gibson G, Wynne A, Hudspith B, Brostoff J, Tuohy K. In vitro studies on colonization resistance of the human gut microbiota to Candida albicans and the effects of tetracycline and Lactobacillus plantarum LPK. Curr Issues Intest Microbiol. 2003 Mar;4(1):1-8.
13. Ström K, Schnürer J, Melin P. Co-cultivation of antifungal Lactobacillus plantarum MiLAB 393 and Aspergillus nidulans, evaluation of effects on fungal growth and protein expression.FEMS Microbiol Lett. 2005 May 1;246(1):119-24.
14. Sjögren J, Magnusson J, Broberg A, Schnürer J, Kenne L. Antifungal 3-hydroxy fatty acids from Lactobacillus plantarum MiLAB 14. Appl Environ Microbiol. 2003 Dec;69(12):7554-7.
15. Probiotic Comparison Testing. Unpublished data. August 23, 2007.
16. Prescott LM, Harley JP, Klein DA.Microbial Growth. In: Microbiology, 2nd edition. Dubuque, IA: Wm. C. Brown Communications, Inc.; 1993: 112-5.
17. Probiotic Comparison Testing. Unpublished data. June 3, 2002.

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