Overview

Why take supplemental calcium?

Calcium is the most abundant mineral in the body

Calcium isn't just necessary for healthy bones - it's also required for healthy blood circulation, nerve impulse transmission, muscle contractions, and cell metabolism.†

Research has also demonstrated that calcium may reduce the risk of osteoporosis

Osteoporosis affects middle aged and older persons. A lifetime of regular exercise and a healthy diet that includes calcium builds and maintains good bone health and may reduce the risk of osteoporosis later in life. Daily intakes above 2,000 mg are not likely to provide any additional benefit to bone health.

Most diets don't meet the body's need for calcium

Most Americans above the age of 9 don't get the calcium they need through diet alone. Supplementation with a readily absorbable calcium that combines magnesium and vitamin D can help fill the nutritional gaps often seen in the average diet.†

Why take Liquid Calcium Magnesium?

Your body absorbs this supplement easily

Liquid Calcium Magnesium features a highly concentrated, bioavailable form of calcium plus magnesium in a 1:1 Calcium/Magnesium ratio.†

Provides synergistic bone-enhancing nutrients.†

Liquid Calcium Magnesium also includes vitamin D and boron for maximum bone health support.†

Great for all ages

This pleasant-tasting, vegetarian alternative to large tablets or capsules is recommended for adults and children alike. Plus, it has the same great taste from the first delicious spoonful to the last!

Directions

One tablespoon once or twice daily. Shake well before each use.

Interactions and Depletions

Technical Data

Description

Liquid Calcium Magnesium (Vanilla Shake flavor) was created as a pleasant-tasting, vegetarian alternative to large tablets or capsules. The formula offers flexible dosing in a convenient, easy-to-use delivery system.

The Liquid Calcium Magnesium formulation emphasizes key nutrients for the support and maintenance of healthy bone and bone structure.^† The formula includes calcium that may reduce the risk of osteoporosis. Osteoporosis affects middle aged and older persons. A lifetime of regular exercise and a healthy diet that includes calcium builds and maintains good bone health and may reduce the risk of osteoporosis later in life.1 Daily intakes above 2,000 mg are not likely to provide any additional benefit to bone health.

Liquid Calcium Magnesium Vanilla Shake Flavored

• 1:1 Cal/Mag ratio
• Includes boron and vitamin D to enhance calcium absorption^†
• Recommended for all age groups

Structure/Function

Liquid Calcium Magnesium supports optimum bone health.^† The formula provides synergistic bone-enhancing nutrients.^†

How Does It Work?

The calcium, magnesium, and vitamin D in Liquid Calcium Magnesium provide readily absorbable nutrients that support the maintenance of healthy bones.^†

Development of Bone

Bone is living tissue, a matrix of collagen, bolstered by calcium (primarily) and other minerals. Its very design allows for great strength and versatility. The human skeleton is light and mobile, and easily moved by muscle.

Bone tissue is continually remodeled by the body. Two bone cells, the similarly-named osteoblasts and osteoclasts are mainly responsible for the process.^2,3

Osteoblasts synthesize and secrete osteoid, the organic compound of the bony matrix. Osteoblasts also help “mineralize” the organic matrix of bone, bringing calcium, magnesium, and other minerals into the structure. Osteoclasts, on the other hand, are responsible for the resorption of the bone matrix and the release of calcium and phosphate from bone.^2,3

In an ideal balance, bone tissue being replaced equals reabsorbed bone. Three major factors that affect this are:

• Biochemical: includes hormones, growth factors and cytokines that modulate the bone-building process
• Mechanical: includes weight bearing stress, which fuels the generation of new bone tissue and mineral replacement
• Nutritional: includes the proper intake of calcium, magnesium and vitamin D to help build the bone matrix²

Any imbalance in this process can be a challenge for bone health.^3-5 Supplements containing calcium and other bone-building nutrients can support healthy bones and bone structure.^†3

Ingredient	Benefit
Calcium	While calcium's main role in the body is maintaining bones and teeth, this mineral-the most abundant in the body-has a wide range of biologic roles. Calcium is required for healthy blood circulation, nerve impulse transmission, muscle contractions, and cell metabolism.†6 Calcium supplementation has also been studied for its possible role supporting healthy cell development in the colon, the retention of healthy blood pressure that is already within the normal range, supporting healthy body mass index (BMI), and supporting healthy lipid levels (both low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol levels) already within the normal limits.†7-12 Research has also demonstrated that calcium supplements, if taken regularly, may reduce the risk of osteoporosis.13-16 Osteoporosis affects middle aged and older persons. A lifetime of regular exercise and a healthy diet that includes calcium builds and maintains good bone health and may reduce the risk of osteoporosis later in life.†1 Daily intakes above 2,000 mg are not likely to provide any additional benefit to bone health.
Magnesium	As with calcium, most of the magnesium in the body is found in skeletal structures. Magnesium assists in numerous enzymatic functions throughout the body.17 Magnesium supplementation may also support the retention of healthy cholesterol levels already within normal limits and is well-known for supporting the immune system.†18, 19 Clinical studies have found that magnesium supports healthy bones in young adults.†20, 21
Vitamin D	Ergocalciferol is a vegetarian form of vitamin D, a fat-soluble vitamin that is stored at lesser amounts than other fat-soluble vitamins, requiring consistent and adequate intake.22 The primary functions of vitamin D are enhancing the absorption of calcium and phosphorus from the intestines and bone mineralization and mineral homeostasis through the regulation of blood calcium levels.†23, 24 Clinical studies have indicated that vitamin D supports healthy bone formation.†24, 25 Supplementation with vitamin D has been shown to support healthy musculoskeletal function in older adults.†26 Vitamin D with calcium supplements have also been demonstrated to support oral health, including healthy teeth.†27
Boron	Boron is a trace mineral that works with calcium and magnesium to support healthy bone mineral metabolism.†28 Boron supplementation has been shown to decrease urinary excretion of both calcium and magnesium.†28

Conclusion
Proper calcium intake early in life can provide the greatest benefits to overall bone health.^† However, most Americans above the age of 9 do not get the calcium they need through diet alone. Supplementation with an readily absorbable calcium that combines magnesium and vitamin D can help fill the nutritional gaps often present in the average diet.^†29

Recommendations

One tablespoon once or twice daily. Shake well before each use.

Precautions

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

How Is It Supplied?

• 070067;16 fl. oz (437 ml)

Storage Recommendations

Store at controlled room temperature, 59° to 86°F (15° – 30°C).

References

1. National Institutes of Health. NIH Consensus Development Program: Osteoporosis Prevention, Diagnosis and Therapy. Available at: http://consensus.nih.gov/2000/2000Osteoporosis111html.htm. Accessed on September 7, 2006.
2. Porth CM. Bone. In: Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 2002:1312-1314.
3. Guyton AC, Hall JE. Deposition and resorption of bone. In: Textbook of Medical Physiology.10th Ed. Philadelphia, Pa: W.B. Saunders Company; 2000: 903-904.
4. Porth CM. Osteoporosis. In: Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 2002:1355-1358.
5. Holmes NH, ed. Osteoporosis. In: Professional Guide to Diseases. 7th ed. Springhouse, Pa: Springhouse Corporation, 2001: 591-592.
6. Weaver CM, Heaney RP. Calcium. In: Shils ME, Olson JA, Shine M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999: 141-155.
7. Lupton JR, Steinbach G, Chang WC, et al. Calcium supplementation modifies the relative amounts of bile acids in bile and affects key aspects of human colon physiology. J Nutr. 1996;126:1421-8.
8. Bostick RM, Fosdick L, Wood JR, et al. Calcium and colorectal epithelial cell proliferation in sporadic adenoma patients: a randomized, double-blinded, placebo-controlled clinical trial. J Natl Cancer Inst. 1995;87:1307-15.
9. Jolma P, Kalliovalkama J, Tolvanen JP, et al. High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension. Am J Physiol Heart Circ Physiol. 2000;279:H1036-43.
10. Davies KM, Heaney RP, Recker RR, Lappe JM, Barger-Lux MJ, Rafferty K, Hinders S. Calcium intake and body weight. J Clin Endocrinol Metab. 2000;85:4635-8.
11. Heaney RP, Recker RR, Lappe JM. Effects of calcium supplementation on serum lipid levels in postmenopausal women. Am J Med.2003;114:620-621.
12. Reid IR, Mason B, Horne A, et al. Effects of calcium supplementation on serum lipid concentrations in normal older women: a randomized controlled trial. Am J Med. 2002;112:343-347.
13. Ruml LA, Sakhaee K, Peterson R, Adams-Huet B, Pak CY. The effect of calcium citrate on bone density in the early and mid-postmenopausal period: a randomized placebo-controlled study. Am J Ther. 1999;6:303-11.
14. Cornell CN, Lane JM, Poynton AR. Orthopedic management of vertebral and long bone fractures in patients with osteoporosis. Clin Geriatr Med. 2003;19:433-55.
15. Campbell BG, Ketchell D, Gunning K. Do calcium supplements prevent postmenopausal osteoporotic fractures? J Fam Pract. 2003;52:234, 237.
16. Moyad MA. Osteoporosis-Part II: Dietary and/or supplemental calcium and vitamin D. Urol Nurs. 2002;22:405-9.
17. Grodner M, Anderson SL, DeYoung S. Magnesium. In: Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby; 2000: 224.
18. Vaskonen T, Mervaala E, Seppanen-Laakso T, Karppanen H. Diet enrichment with calcium and magnesium enhances the cholesterol-lowering effect of plant sterols in obese Zucker rats. Nutr Metab Cardiovasc Dis. 2001;11:158-67.
19. Mooren FC, Golf SW, Volker K. Effect of magnesium on granulocyte function and on the exercise induced inflammatory response. Magnes Res. 2003;16:49-58.
20. Dimai HP, Porta S, Wirnsberger G, et al. Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab. 1998;83:2742-8.
21. Rude RK, Kirchen ME, Gruber HE, Meyer MH, Luck JS, Crawford DL. Magnesium deficiency-induced osteoporosis in the rat: uncoupling of bone formation and bone resorption. Magnes Res. 1999;12:257-67.
22. Grodner M, Anderson SL, DeYoung S. Vitamin D. In: Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby; 2000: 194-198.
23. van Leeuwen JP, van Driel M, van den Bemd GJ, Pols HA. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit Rev Eukaryot Gene Expr. 2001;11:199-226.del Puente A, Esposito A, Savastano S, Carpinelli A, Postiglione L, Oriente P. Dietary calcium intake and serum vitamin D are major determinants of bone mass variations in women. A longitudinal study. Aging Clin Exp Res. 2002;14(5):382-8.
24. Kyriakidou-Himonas M, Aloia JF, Yeh JK. Vitamin D supplementation in postmenopausal black women. J Clin Endocrinol Metab. 1999;84:3988-90.
25. Feskanich D, Willett WC, Colditz GA. Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women. Am J Clin Nutr. 2003;77:504-11.
26. Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res. 2003;18:343-51.
27. Krall EA, Wehler C, Garcia RI, Harris SS, Dawson-Hughes B. Calcium and vitamin D supplements reduce tooth loss in the elderly. Am J Med. 2001;111:452-6.
28. Nielsen FH. Biochemical and physiologic consequences of boron deprivation in humans. Environ Health Prospect. 1994;102 Suppl. 7:59-63.
29. Bone Health and Osteoporosis: A Report of the Surgeon General. Chapter 7, “Lifestyle Approaches to Promote Bone Health.” Available at: http://www.surgeongeneral.gov/library/bonehealth/chapter_7.html#Calcium. Accessed: August 15, 2006.

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