Overview

Clinically proven to support healthy joint function and range of motion^†

• Up to 80% of participants in clinical trials experienced significant joint health support.^†1,2
• Eleven clinical trial have all found positive benefits

Also supports healthy bronchial airways^†

As an added benefit, Lyprinol has also been shown to support healthy bronchial airways.^†3

Free from harmful levels of toxins, metals and impurities

• There is a growing concern about the safety of seafoods and ocean-harvested ingredients.
• You can be assured that Lyprinol is free from harmful levels of toxins, metals and other impurities.

Why use this product?

It helps protect cartilage and support joint health naturally.^† Lyprinol is a great source of omega-3 polyunsaturated fatty acids, including EPA and DHA. It makes a great alternative or adjunct supplement to fish oil or flax oil.
 

^{1. Cho SH, Jung YB, Seong SC, et al. Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial. Allerg Immunol (Paris). 2003;35:212-6.
2. Whitehouse MW, Macrides TA, Kalafatis N, Betts WH, Haynes DR, Broadbent J. Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel. Inflammopharmacology. 1997;5:237-246.
3. Emelyanov A, Fedoseev G, Krasnoschekova O, Abulimity A, Trendeleva T, Barnes PJ. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur Respir J. 2002;20:596-600.}

Directions

Take 2 softgels twice daily for 3-6 weeks; then 1 to 2 softgels per day. The daily level needed to obtain maximum benefit may vary from person to person.

Pill Size

Interactions and Depletions

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Technical Data

Description

Enzymatic Therapy's Miracle from the Sea Lyprinol is a natural, unique and patented stable extract of green-lipped mussels. Backed by over 30 years of research, Lyprinol has been clinically proven to help support healthy bronchial airways, healthy joint function, and normal range of motion.^†1-13

Lyprinol:

• Uses a patented extraction process that protects key compounds (U.S. Patent # 4,455,298)
• The subject of eleven clinical trials, all showing significant positive effect
• Clinically proven to support healthy joint function, range of motion, and healthy airways^†
• Provides natural non-polar lipids for joint and bronchial airway support^†
• Free from harmful levels of toxins, metals and impurities

Structure/Function
Lyprinol is clinically proven to support healthy joint function.^† Lyprinol supports normal range of motion.^†

How Does It Work?

Lyprinol contains a unique grouping of rare omega-3 fatty acids derived from the non-polar lipids of New Zealand's green lipped mussel (Perna canaliculus). This combination of omega-3 fatty acids is wholly unique to this species and is not found in any other living system.^1-6 While anecdotal evidence and observational research was altogether positive for the green lipped mussel's ability to support human health, initial clinical studies were inconsistent.

Early researchers erred when they suggested that freezing and powdering the mussels would provide the same benefits as raw mussel flesh. These early attempts caused oxidation of the non-polar lipids and resulted in completely inert materials.^{5, 6} Perseverance and years of exacting research finally resulted in a patented process that stabilizes the non-polar lipids before the green-lipped mussels are processed.⁷

To date, there is only one nutritional supplement utilizing this patented, stabilized green lipped mussel powder, Miracle of the Sea Lyprinol^™. When comparing the outcomes of clinical research using stabilized green lipped mussel powders with active non polar lipids to outcomes from research using unstabilized green lipped mussel powders, it's evident that stabilization is crucial.


Research
The amount of research conducted on Lyprinol is impressive and quite unique for a dietary supplement. In a 1998 study comparing the effectiveness of Lyprinol stabilized green lipped mussel (Perna canaliculus) with the raw green lipped mussel powder, both forms supported healthy joint function and normal range of motion.^†8 The only difference was in speed of action: the Lyprinol extract achieved a more rapid response, demonstrating that the nutritional supplement Miracle form the Sea Lyprinol contains the same key compounds present in the raw mussel.⁸

Experimental studies have shown that Lyprinol is effective in supporting pathways responsible for the production of certain bronchio-pulmonary compounds.^†9 A double-blind, placebo-controlled clinical trial randomized forty six subjects to receive two capsules of Lyprinol or placebo, twice daily for eight weeks. There was significant support of bronchial airways in the Lyprinol group compared to the placebo group.^†9

To validate the clinical efficacy and safety of stabilized green lipped mussel in supporting healthy joint function and healthy range of motion, sixty participants received Lyprinol at two capsules twice a day.^† After treatment periods (four and eight weeks), assessment with visual analogue scale, Lequesne functional index, subjective and objective global assessments. Scores at the four week period demonstrated that 53% of the participants experienced significant support for joint health and range of motion.^† At the completion of the eight week treatment period, scores had increased dramatically, demonstrating that 80% of the participants experienced enhanced support of joint function and range of motion.^†10 There were no reported adverse events.¹⁰

Research has demonstrated that the extract of New Zealand green-lipped mussel in Lyprinol functions as a 5-lipoxygenase pathway inhibitor.^† Inhibition of the 5-lipoxygenase pathway supports healthy leukotriene levels.^† In recent research, Lyprinol was compared to flaxseed oil, evening primrose oil, salmon oil, and fish oil. On a dosage per body weight basis, Lyprinol was demonstrated to be:

• 100 times more potent than fish oil.
• 125 times more potent than green lipped mussel powder.
• 175 times more potent than evening primrose oil.
• 175 times more potent than salmon oil.
• 200 times more potent than flaxseed in supporting healthy joints.^†11

Scientific inquiry of Lyprinol is continuing. New research has demonstrated a possible role for stabilized green lipped mussel powder with active non polar lipids in support of healthy digestive tracts.^†12 Calls for comparison studies to aloes signify Lyprinol's validity in support of human health.^†13


Conclusion
Unique among nutritional supplements, Miracle from the Sea Lyprinol ides evidence based nutritional support for healthy joints and bronchial airways.^† Ongoing clinical studies have demonstrated Lyprinol to be safe and effective.

Recommendations

Take 2 softgels twice daily for 3-6 weeks; then 1 to 2 softgels per day. The daily level needed to obtain maximum benefit may vary from person to person.

Precautions

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Note: Characteristic odor and cloudiness which may occur are normal and do not affect product quality

How Is It Supplied?

• 02416;60 softgels

References

1. Highton TC, McArthur AW. Pilot study on the effect of New Zealand green mussel on rheumatoid arthritis. N Z Med J. 1975;81:261-2.
2. Miller TE, Ormrod D. The anti-inflammatory activity of Perna canaliculus (NZ green lipped mussel). N Z Med J. 1980;92:187-93.
3. Sinclair AJ, Murphy KJ, Li D. Marine lipids: overview "news insights and lipid composition of Lyprinol". Allerg Immunol (Paris). 2000;32:261-71.
4. Miller TE, Dodd J, Ormrod DJ, Geddes R. Anti-inflammatory activity of glycogen extracted from Perna canaliculus (NZ green-lipped mussel). Agents Actions. 1993;38 Spec No:C139-42.
5. Murphy KJ, Mann NJ, Sinclair AJ. Fatty acid and sterol composition of frozen and freeze-dried New Zealand Green Lipped Mussel (Perna canaliculus) from three sites in New Zealand. Asia Pac J Clin Nutr. 2003;12:50-60.
6. Halpern GM. Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol). Allerg Immunol (Paris). 2000;32:272-8.
7. United States Patent and Trademark Office Website. McFarlane SJ, Croft JE. Pharmaceutical preparations with gastro-protective action. US Patent 4,455,298. Issued June 19, 1984. Accessed on September 20, 2006. Available at: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4,455,298.PN.&OS=PN/4,455,298&RS=PN/4,455,298.
8. Gibon SLM, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus; a randomized trial. Complement Ther Med.1998; 6:122-126.
9. Emelyanov A, Fedoseev G, Krasnoschekova O, Abulimity A, Trendeleva T, Barnes PJ. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial. Eur Respir J. 2002;20:596-600.
10. Cho SH, Jung YB, Seong SC, et al. Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial. Allerg Immunol (Paris). 2003;35:212-6.
11. Whitehouse MW, Macrides TA, Kalafatis N, Betts WH, Haynes DR, Broadbent J. Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel. Inflammopharmacology. 1997;5:237-246.
12. Tenikoff D, Murphy KJ, Le M, Howe PR, Howarth GS. Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease. J Gastroenterol. 2005;40:361-5.
13. Whitehouse MW. Call for a trial of Lyprinol, an over-the-counter 5-lipoxygenase inhibitor:comment on the article by Kowal-Bielecka et al. Arthritis Rheum. 2002;46:1977-8.

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