Overview

Targeted nutrition for children’s immune systems.^†

Sea Buddies^™ Immune Defense^† features elderberry, zinc and Vitamins C, B6, and A to strengthen the immune system and to help your child feel better faster.^† Research shows that certain vitamins, minerals, and herbal extracts support optimal immune health in children.^†

Recommended with other products.

For a double boost of immune support, children can use Sea Buddies^™ Immune Defense^† with Esberitox^® supercharged echinacea.^†

Great tasting chewable tablet.

The kid-tested Sparkleberry flavor makes feeling good taste great!^†

Why use this product?

Because children’s immune systems face many challenges.^† Children are in environments that challenge their healthy immune system every day. Supplements can help maintain their natural defenses, something as parents you will appreciate.^†

Directions

Chew one tablet daily.
When extra support is desired:
Children age two to less than four years: chew two tablets daily.
Children age four years and over: chew two to four tablets daily.

Pill Size

Interactions and Depletions

Technical Data

Description

Sea Buddies™ Immune Defense† is a daily immune formula for children age one to twelve years of age in a chewable tablet.

How Does It Work?

The major components of children's immune systems include the spleen, a very large thymus gland, the lymphatic system, bone marrow, white blood cells, antibodies, and certain hormones. Optimal nutrition provides needed vitamins, minerals, and other nutrients to support the function and ability of healthy white blood cells and biochemicals to support a healthy immune system.^1-3 Supplemental antioxidants provide protection from free radicals (potentially damaging by-products of the body's metabolism).^†4,5

Studies have demonstrated that children's diets influence the current health of their immune systems, as well as their immune system functioning later on into adolescence and adulthood.^6,7 The ingredients in Sea Buddies™ Immune Defense† work together, some synergistically, to provide support for healthy immune system functioning.†

Sea Buddies™ Immune Defense† Ingredient	Immune Supportive Action
Vitamin A (as beta carotene)	The vitamin A in Surf Buddies™ Immune Defense† is pure beta-carotene, the most active vitamin A precursor. Beta-carotene is converted to vitamin A by the body only as needed. Vitamin A supports the production of healthy lysozymes, important immune enzymes found in tears and saliva, and supports the health of the thymus gland, a vital childhood immune organ.† 8-10
Vitamin C (ascorbic acid and as sodium ascorbate)	Vitamin C provides support for healthy skin integrity 11and supports the health of bronchioles and other breathing structures.†12,13 Vitamin C levels may be affected by immune system stressors.†14
Vitamin B6 (as pyridoxine HCl)	B6 supports the health of immune organs (thymus, spleen, and lymph nodes). Vitamin B6 also supports the healthy production of lymphocyte generated antibodies.†15-17
Zinc (as zinc ascorbate)	Zinc has been shown in clinical studies to support healthy immune system processes in children.†18-20
European Black Elderberry Fruit (Sambucus nigra)	Clinically studied, elderberry extract supports healthy immune system responses.†21-23

Conclusion
The health of children's immune systems is closely linked to nutrition. Research has demonstrated that certain vitamins, minerals, and herbal extracts support optimal immune health in children.†^24,25 Sea Buddies™ Immune Defense† provides nutritional support of healthy immune system function with vitamins A, C, and B6, the mineral zinc, and extracts of European black elderberry fruit.† Mindful that children's nutritional supplements are only effective if children will take them, Sea Buddies™ Immune Defense† chewable tablets have a great naturally fruity taste that children like.

Recommendations

Chew one tablet daily. When extra support is needed: Children age two to less than 4 years: chew two tablets daily. Children age four years and over: chew two to four tablets daily.

Precautions

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

How Is It Supplied?

60 chewable tablets.

Storage Recommendations

Store at controlled room temperature, 59° to 86°F (15°-30°C).

References

1. Field CJ, Johnson IR, Schley PD. Nutrients and their role in host resistance to infection. J Leukoc Biol. 2002 Jan;71(1):16-32.
2. Chandra RK. Food allergy and nutrition in early life: implications for later health. Proc Nutr Soc. 2000;59:273-7.
3. Seaton A, Devereux G. Diet, infection and wheezy illness: lessons from adults. Pediatr Allergy Immunol. 2000;11:37-40.
4. Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res. 2001;475:7-20.
5. Tubiana M. Cancer prevention. Acta Oncol. 1999;38:689-94.
6. Lamont DW, Parker L, Cohen MA, et al. Early life and later determinants of adult disease: a 50 year follow-up study of the Newcastle Thousand Families cohort. Public Health. 1998;112:85-93.
7. Yajnik CS. The lifecycle effects of nutrition and body size on adult adiposity, diabetes and cardiovascular disease. Obes Rev. 2002;3:217-24.
8. Jason J, Archibald LK, Nwanyanwu OC, et al. Vitamin A levels and immunity in humans. Clin Diagn Lab Immunol. 2002;9:616-21.
9. Ross AC. Vitamin A and retinols: functions. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999: 317-318.
10. Stephensen CB. Vitamin A, infection, and immune function. Annu Rev Nutr. 2001;21:167-192.
11. Boyce ST, Supp AP, Swope VB, Warden GD. Vitamin C regulates keratinocyte viability, epidermal barrier, and basement membrane in vitro, and reduces wound contraction after grafting of cultured skin substitutes. J Invest Dermatol. 2002;118:565-72.
12. Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, et al. Antioxidant Supplementation and Lung Functions among Children with Asthma Exposed to High Levels of Air Pollutants. Am J Respir Crit Care Med. 2002;166:703-9.
13. Strauss RS. Environmental tobacco smoke and serum vitamin C levels in children. Pediatrics. 2001 Mar;107(3):540-2.
14. Fleming T., ed. Vitamin C. In: PDR® for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 486-498.
15. Leklem JE. Vitamin B6. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:413-421.
16. Kwak HK, Hansen CM, Leklem JE, Hardin K, Shultz TD. Improved vitamin B-6 status is positively related to lymphocyte proliferation in young women consuming a controlled diet. J Nutr. 2002;132:3308-13.
17. Balabolkin II, Gordeeva GF, Fuseva ED, Dzhunelov AB, Kalugina OL, Khamidova MM. Use of vitamins in allergic illnesses in children. Vopr Med Khim. 1992;38:36-40.
18. Sazawal S, Black RE, Jalla S, Mazumdar S, Sinha A, Bhan MK. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: double-blind, controlled trial. Pediatrics. 1998;102:1-5.
19. Prasad AS, Fitzgerald JT, Bao B, Beck FW, Chandrasekar PH. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:245-52.
20. Godfrey JC, Godfrey NJ, Novick SG. Zinc for treating the common cold: review of all clinical trials since 1984. Altern Ther Health Med. 1996;2:63-72.
21. Zakay-Rones Z, Varsano N, Zlotnik M, et al.Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med. 1995;1:361-9.
22. Espin JC, Soler-Rivas C, Wichers HJ, Garcia-Viguera C. Anthocyanin-based natural colorants: a new source of antiradical activity for foodstuff. J Agric Food Chem. 2000;48:1588-92.
23. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw. 2001;12:290-6.
24. Kelly D, Coutts AG. Early nutrition and the development of immune function in the neonate. Proc Nutr Soc. 2000;59:177-85.
25. Lopez N, de Barros-Mazon S, Vilela MM, Silva CM, Ribeiro JD. Genetic and environmental influences on atopic immune response in early life. J Investig Allergol Clin Immunol. 1999;9:392-8.

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