Overview
Why should children support their immune system naturally?
Because any kid's immune system faces a lot of challenges.†
Think of the environments your children are in every day, and you'll probably agree that a little extra help for their immune systems is simply sensible.†
Why use ImmunoKids®?
It's designed by doctors, and formulated for kids.
ImmunoKids® is a dietary supplement specifically formulated by leading physicians in child neurological development for immune function support.†
It is a great source of natural immune-system boosters.†
Among its unique blend of ingredients, ImmunoKids® includes vitamin C, bioflavonoids, and grape seed as well as French maritime pine bark. It also offers the protective effects of zinc, along with aloe and standardized TOA-free cat's claw extracts.†
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Directions
Take 3 UltraCaps
daily with food or as directed by your healthcare practitioner.
For best results, take in 2 or 3 divided doses. If desired, UltraCaps may be opened and contents mixed into cold food.
Pill Size
Interactions and Depletions
Technical Data
Description
ImmunoKids dietary supplement is specifically formulated by leading physicians in child neurological development to support healthy immune defense in children.
A part of the Learner's Edge line of supplements,
ImmunoKids supports a healthy functioning immune system, which is critical to the development and function of the nervous system.
Formulated by leading physicians, the Learner's Edge
® system of products were designed to be used together to address learning issues in children from different nutritional approaches.
This natural support system gives children the edge they need in today's complex and often unhealthy environment, with support for natural detoxification, digestion, cognition, immune function, and growth.
ImmunoKids:
- Formulated by Dr. Jeff Bradstreet, a leading physician in child neurological development
- Provides clinically effective ingredients
- Includes Leucoselect® Phytosome, a phosphtidylcholine-bound grape seed extract for enhanced bioavailability
- Contains Saventaro® brand cat's claw, a clinically studied extract, free of tetracyclic oxindole alkaloids (TOAs)
Introduction
Healthy immune function is important for neurological development in children.
1 The immune system's role is to protect the body. Its workings are complex; involving different organs, specialized cells, hormone messengers and the lymphatic system which recognize and defend against foreign matter. Research is showing that components of the immune system may play a role in support of neurodevelopment.
2 How Does It Work?
The ingredients in
ImmunoKids® dietary supplement have been shown in studies to help support immune system function and immune defense in children.
The ingredients include:
| Ingredient | Benefit |
| Vitamin C |
Vitamin C is one of the most important nutrients to the human body and contributes to a number of biomechanical processes. Vitamin C levels are associated with immune system function in children.3
Vitamin C is an exceptional antioxidant, operating as a valuable free-radical scavenger to protect cells from reactive oxygen molecules.4 Working inside human cells, vitamin C also has the ability to inhibit oxidative mitochondrial DNA damage, thereby protecting cellular health.5
Vitamin C acts as a powerful supporting component to the immune system. Due to its antioxidant properties, it is highly concentrated in leukocytes (white blood cells) and is used rapidly to enhance leukocyte response and function. Linus Pauling, a scientist and Nobel-prize winner, recommended vitamin C to boost immunity and promote longevity. Several studies have shown that vitamin C supports the body's ability to protect itself from foreign matter.1,7 It also supports the immune response to environmental triggers.1 |
| Zinc |
Zinc is an essential micronutrient that supports a wide range of physiological functions. Recent zinc research has investigated its role in the support of enzyme activity, immune health, cell integrity, and gene transcription.
While researchers are not certain how zinc precisely boosts a child's immunity, they think that zinc might improve the body's defenses by either enhancing the body's immune status or improving the immune system's ability to recover.9,10,11
Zinc's benefits for the immune system have also been well documented. In one study, zinc supported the healthy generation of T-cells and natural killer cells, important white blood cells of the immune system. In another study, zinc was found to be required for the production of immune bio-chemicals, including tumor necrosis factor alpha, interleukin-1beta, and certain cytokines. Zinc also functions as an antioxidant agent.12 |
| IP-6 and Inositol |
Inositol is a water soluble, ubiquitous 6-carbon sugar found in beans, citrus fruit, nuts, rice, veal, pork, and wheat germ.13 Inositol supports healthy nerve transmission, healthy fat metabolism, and is needed for cell membrane structure and integrity.14,15,16,17,18,19
Inositol hexaphosphate (IP-6 or phytic acid) is an inositol molecule with six phosphate groups attached; it is abundant in cereals and legumes.20,21 In smaller amounts, IP-6 is contained in most mammalian cells, where it supports cellular functions.22,23,24,25,26,27,28 In addition, IP-6 functions as an antioxidant.29,30
While independently these molecules support immune health, the unique combination of IP-6 and inositol functions synergistically. Research indicates that IP-6 and inositol support stronger healthy cell development and increased natural killer cell activity as opposed to either compound alone.31,32,33 |
| Grape Seed |
Grape seed extract is a potent natural antioxidant; its use dates back to the 5th century B.C.34 Today, it is the antioxidant activity of V. vinifera that is of major interest in the nutrition community.
Procyanidins, the key components of grape seed extract, are found in abundance in the plant kingdom. Procyanidins are a group of polyphenolic bioflavanoids.35 They are bound to one another and are referred to collectively as procyanidolic oligomers (PCOs). The antioxidant activity of PCOs have been reported to exhibit a wide range of biological properties against free radicals.36,37 PCOs have also been shown to protect DNA from damage and enhance the growth and integrity of normal cells.35,38
In addition, PCOs have been shown to provide a higher level of antioxidant activity against oxidative damage than vitamin E, C or a combination of vitamins E and C.35,39,40,41 Research has also shown that PCOs interact synergistically with vitamin E in the body, slowing the consumption of vitamin E and partially regenerating it to an extent comparable to vitamin C.34 |
| Pine Bark |
Pine bark extract is made from the bark of a European coastal pine tree called the Landes or maritime pine, whose scientific name is Pinus maritima. The maritime pine is a member of the Pineaceae family. Research shows pine bark supports healthy microbial balance in the body.42 It also supports healthy pulmonary functions and enhances the body's repair capabilities.43,44
Procyanidins, key components in pine bark, protect against oxidative stress in several cell systems by doubling the intracellular synthesis of anti-oxidative enzymes and by acting as a potent scavenger of free radicals.44,45 It has an important role in regeneration and protection of vitamin C and E and enhances the body's natural anti-inflammatory responses.44 In addition, it has also been shown to enhance cognitive function.44 |
| Cat's Claw |
Saventaro® is a unique extract, made from the root extract of Uncaria tomentosa. It has been shown to both enhance natural immunity and modify the acquired immune system.® To the Asháninka Indians in the Central Peruvian rain forest where Saventaro cat's claw is harvested, the pentacyclic alkaloid-chemotype of U. tomentosa is a beneficial plant that they call savéntaro (saveshi=plant, antearo=potent).46 The root of Uncaria tomentosa contains significantly higher total alkaloids than the bark.47 In addition, studies show that pentacyclic oxindole alkaloids (POAs),the active ingredient in Cat's Claw, have important immune supportive health properties.48,49,50 |
| Aloe Vera |
Aloe vera's use can be traced back 6,000 years to early Egypt, where the plant was depicted on stone carvings.50 Studies have shown that aloe vera supports healthy microflora balance.51 It also enhances immune defenses against foreign matter.52,53 |
| Elderberry |
Elderberry extract has been used as a traditional medicine for hundreds of years to enhance the immune system.54 Studies show elderberry extract enhances cellular defenses and spurs important immune cells into action.55,56 Elderberry extract activates the immune system by increasing levels of cytokine production, an important compound that supports the body's natural anti-inflammatory response.56 Elderberry extract may enhance recovery time.57 |
| Monolaurin |
Monolaurin is a form of the fatty acid called lauric acid. It is found in human and coconut milk. Monolaurin enhances immune defenses against foreign matter and supports healthy microflora balance.58,59 |
Conclusion
ImmunoKids® dietary supplement enhances immune system function in order to support development and function of the nervous system in children.
Recommendations
Take 3 UltraCaps
daily with food, or as directed by your healthcare practitioner. For best results, take in 2 or 3 divided doses. If desired, UltraCaps may be opened and contents mixed into cold food.
Precautions
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
How Is It Supplied?
Storage Recommendations
Store at controlled room temperature, 59° to 86°F (15° – 30°C).
References
- Gupta S. Immunological treatments for autism. J Autism Dev Disord. 2000 Oct;30(5):475-9.
- Ashwood P, Van De Water J. A Review of Autism and the Immune Response. Clinical & Developmental Immunology. June 2004;11(2):165-74.
- Fleming T. ed. Vitamin C. In: PDR® for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001:486-498.
- Carr AC, Frei B.Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999 Jun;69(6):1086-107.
- KC S, Carcamo JM, Golde DW. Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury. FASEB J. 2005 Oct;19(12):1657-67.
- Murray M, Pizzorno J. Encyclopedia of Natural Medicine. 2nd edition. Prima Health Publishing. Rocklin, CA. 1998:155.
- Field CJ, Johnson IR, Schley PD. Nutrients and their role in host resistance to infection. J Leukoc Biol. 2002 Jan;71(1):16-32.
- Fleming T., ed. Zinc. In: PDR® for Nutritional Supplements. Montvale, NJ: Medical Economics Company;534-520.
- Sazawal S, Black RE, Jalla S, Mazumdar S, Sinha A, Bhan MK. Zinc supplementation
reduces the incidence of acute lower respiratory infections in infants and preschool
children: double-blind, controlled trial. Pediatrics. 1998;102:1-5.
- Prasad AS, Fitzgerald JT, Bao B, Beck FW, Chandrasekar PH. Duration of symptoms and
plasma cytokine levels in patients with the common cold treated with zinc acetate. A
randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2000;133:245-52.
- Godfrey JC, Godfrey NJ, Novick SG. Zinc for treating the common cold: review of all
clinical trials since 1984. Altern Ther Health Med. 1996;2:63-72.
- Prasad AS. Zinc: mechanisms of host defense. J Nutr. 2007 May;137(5):1345-9.
- Zhou JR, Erdman JW Jr. Phytic acid in health and disease. Crit Rev Food Sci Nutr. 1995;35:495-508.
- Holub BJ. The nutritional significance, metabolism, and function of myo-inositol and phosphatidylinositol in health and disease. Adv Nutr Res. 1982;4:107-141.
- Colodny L, Hoffman RL. Inositol--clinical applications for exogenous use. Altern Med Rev. 1998;3:432-447.
- Gordon PR, Mawhinney TP, Gilchrest BA. Inositol is a required nutrient for keratinocyte growth. J Cell Physiol. 1988;135:416-424.
- Downes CP, Macphee CH. Myo-inositol metabolites as cellular signals. Eur J Biochem. 1990;193:1-18.
- Sun XY, Edvinsson L, Yoo H, Wahlestedt C, Hedner T. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. J Cardiovasc Pharmacol. 1995;25:696-704.
- Payrastre B, Missy K, Giuriato S, Bodin S, Plantavid M, Gratacap M. Phosphoinositides: key players in cell signalling, in time and space. Cell Signal. 2001;13:377-87.
- Sommers C. Natural killer cells. In: Porth CM. Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 1998:197-198.
- Jariwalla RJ.Rice-bran products: phytonutrients with potential applications in preventive and clinical medicine. Drugs Exp Clin Res. 2001;27:17-26.
- Shamsuddin AM. Metabolism and cellular functions of IP6: a review. Anticancer Res. 1999;19:3733-3736.
- Jariwalla RJ. Inositol hexaphosphate (IP6) as an anti-neoplastic and lipid-lowering agent. Anticancer Res. 1999;19:3699-3702.
- Shamsuddin AM, Vucenik I. Mammary tumor inhibition by IP6: a review. Anticancer Res. 1999;19:3671-3674.
- Ishikawa T, Nakatsuru Y, Zarkovic M, Shamsuddin AM. Inhibition of skin cancer by IP6 in vivo: initiation-promotion model. Anticancer Res. 1999;19:3749-3752.
- Vucenik I, Tantivejkul K, Zhang ZS, Cole KE, Saied I, Shamsuddin AM. IP6 in treatment of liver cancer. I. IP6 inhibits growth and reverses transformed phenotype in HepG2 human liver cancer cell line. Anticancer Res. 1998;18:4083-4090.
- Vucenik I, Zhang ZS, Shamsuddin AM. IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice.
Anticancer Res. 1998;18:4091-4096.
- Vucenik I, Kalebic T, Tantivejkul K, Shamsuddin AM. Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res. 1998;18:1377-1384.
- Yang GY, Shamsuddin AM. IP6-induced growth inhibition and differentiation of HT-29 human colon cancer cells: involvement of intracellular inositol phosphates. Anticancer Res. 1995;15:2479-2487.
- Johnson M, Tucci M, Benghuzzi H, Cason Z, Hughes J. The effects of inositol hexaphosphate on the inflammatory response in transformed RAW 264.7 macrophages. Biomed Sci Instrum. 2000;36:21-26.
- Tuersley MD, Best L, Tomlinson S. Inositol uptake and metabolism in neuronal tissue.
J Neurochem. 1988;51:1610-1616.
- Shamsuddin AM, Ullah A, Chakravarthy AK. Inositol and inositol hexaphosphate suppress cell proliferation and tumor formation in CD-1 mice. Carcinogenesis. 1989;10:1461-1463.
- Vucenik I, Yang GY, Shamsuddin AM.Inositol hexaphosphate and inositol inhibit DMBA-induced rat mammary cancer. Carcinogenesis. 1995;16:1055-1058.
- Bombardelli E, Morazzoni P. Vitis vinifera L. Fitoterapia. 1995;4:291-316.
- Bagchi D, Garg A, Krohn RL, et al. Oxygen free radical scavenging abilities of vitamin C and E, and grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol. 1997;95:179-189.
- Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Gen Pharmacol. 1998;5:771-776.
- Joshi SS, Ye X, Liu W, et al. The cytotoxic effects of a novel grape seed proanthocyanidin extract on cultured human cancer cells. Scientific Proceedings. 89th Annual Meeting of the American Association for Cancer Research. San Paulo, Brazil, 1998.
- Ray S, Kumar M, Bagchi D. In vivo abrogation of acetaminophen-induced heptic genoma DNA fragmentation and apoptotic cell death by a novel grape seed proanthocyanidin extract (GSPE). FASEB J. 1998:12.
- Liviero L, Puglisi PP. Antimutagenic activity of procyanidins from Vitis vinifera. Fitoterapia. 1994;3:203-209.
- Sato M, Maulik G, Ray P, Bagchi D, Das D. Cardioprotective effects of a novel IH636 grape seed proanthocyanidin extract. IX Biennial Meeting of the International Society for Free Radical Research. San Paulo, Brazil, 1998.
- Bagchi M, Williams CB, Milnes M, et al. Acute and chronic stress-induced gastrointestinal injury in rats and protection by a novel IH636 grape seed proanthocyanidin extract (GSPE). Free Radic Biolol Med. 1998;25:83.
- Torras MA, Faura CA, Schönlau F, Rohdewald P. Antimicrobial activity of Pycnogenol. Phytother Res. 2005 Jul;19(7):647-8.
- Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 2004;41(8):825-32.
- Blazsó G, Gábor M, Schönlau F, Rohdewald P. Pycnogenol accelerates wound healing and reduces scar formation. Phytother Res. 2004 Jul;18(7):579-81.
- Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther. 2002 Apr;40(4):158-68.
- Reinhard KH. Uncaria tomentosa (Willd.) D.C.: cat's claw, uña de gato, or savéntaro. J Altern Comp Med. 1999;5:143-151.
- Keplinger K, Laus G, Wurm M, Dierich MP, Teppner H. Uncaria tomentosa (Willd.) D.C.-ethnomedicinal use and new pharmacological, toxicological and botanical results. J Ethnopharmacol. 1999;64:23-34.
- Lemaire I, Assinewe V, Cano P, Awang DVC, Aranson JT. Stimulation of interleukin-1 and interleukin-6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Una do Gato). J Ethnopharmacology. 1999;64:109-115.
- Wagner H, Kreutzkamp, Jurcic K. Two alkaloids of Uncaria tomentosa and their phagocytosis-stimulating action. Planto Medica. 1985 Oct(5):419-23.
- Aloe Vera. National Center for Complementary & Alternative Medicine website. Available at: http://nccam.nih.gov/health/aloevera/. Accessed September 29,2008.
- Wang HH, Chung JG, Ho CC, Wu LT, Chang SH. Aloe-emodin effects on arylamine N-acetyltransferase activity in the bacterium Heliobactor pylori. Plant Med. 1998 Mar;64(2):176-178.
- Sydiskis RJ, Owen DG, Lohr JL et al. Inactivation of enveloped viruses by anthraquinones extracted from plants. Antimicrob Agents Chemother. 1991 Dec;35(12):2463.6.
- Hatano T, Uebayashi H, Ito H et al. Phenolic constuituents of Cassis seeds and antibacterial effect of some naphthalenes and anthraquinones on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull. (Tokyo) 1999 Aug;47(8):1121-7.
- Chicon PG. Herbs and the common cold. Adv Nurse Pract. 2000;8:31-2.
- Zakay-Rones Z, Varsano N, Zlotnik M, et al. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med. 1995;1:361-9.
- Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw. 2001;12:290-6.
- Zakay-Rones Z, Thom E, Wollan T, Wadstein J. J Int Med Res. 2004 Mar-Apr;32(2):132-40
- Carpo BG, Verallo-Rowell VM, Kabara J. Novel antibacterial activity of monolaurin compared with conventional antibiotics against organisms from skin infections: an in vitro study. J Drugs Dermatol. 2007 Oct;6 (10):991-8.
- Clarke NM, May JT. Effect of antimicrobial factors in human milk on rhinoviruses and milk-borne cytomegalovirus in vitro. J Med Microbiol. 2000 Aug;49(8):719-23.
Ingredients
| Amount/Serving | %DV |
|
Vitamin C (ascorbic acid)
|
500mg
|
833%
|
|
|
Calcium (as calcium magnesium phytate)
|
65mg
|
7%
|
|
|
Zinc (as zinc sulfate)
|
10mg
|
67%
|
|
|
IP-6 (inositol hexaphosphate) (as calcium magnesium phytate)
|
400mg
|
*
|
|
|
Inositol
|
110mg
|
*
|
|
|
Leucoselect® Phytosome containing 26 mg Grape (Vitis vinifera) Seed polyphenols including procyanidolic oligomers & 55 mg Phosphatidylcholine from soy bean
|
83mg
|
*
|
|
|
European Elder (Sambucus nigra) Berry Extract 4:1
|
40mg
|
*
|
|
|
Pine (Pinus Maritima) Bark Extract 90% polyphenols including procyanidolic oligomers
|
25mg
|
*
|
|
|
Aloe Vera Leaf Gel Extract 200:1
|
20mg
|
*
|
|
|
Monolaurin (as glyceryl monolaurate)
|
10mg
|
*
|
|
|
Saventaro® Cat's Claw (Uncaria tomentosa) Bark Extract 1.3% pentacyclic oxindole alkaloids & free of tetracyclic oxindole alkaloids
|
10mg
|
*
|
|
This product does not contain
- artificial coloring
- artificial flavoring
- corn
- dairy products
- gluten
- ingredients of animal origin
- preservatives
- salt
- sugar
- wheat
- yeast
This product contains natural ingredients; color variations are normal.
Notes
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
ImmunoKids® is a registered trademark of Creations Own, Inc., which is licensed for use to the International Child Development Resource Center (ICDRC) and Integrative Therapeutics, Inc.
Saventaro® is a registered trademark of IMMODAL Pharmaka GmbH
(Austria), and is made in the USA under license from IMMODAL.
Protected by U.S. patents 5,302,611 and 5,723,625. Additional patents pending.
Distributed by an FDA-registered Drug Establishment.
Other Ingredients: vegetable capsule (modified cellulose), ascorbyl palmitate, and cellulose.
UPC Codes: 871791008038
Frequently Asked Questions
Is ImmunoKids® safe for long-term use?
Yes. ImmunoKids®, which enhances immune system function in order to support development and function of the nervous system in children, is safe for long-term use.†
What is Saventaro®?
Saventaro® max-strength cat's claw is a unique extract, made from the root extract of cat's claw (Uncaria tomentosa). It has been shown to both enhance natural immunity and modify the acquired immune system.†
To the Asháninka Indians in the Central Peruvian rain forest where Saventaro cat's claw is harvested, the pentacyclic alkaloid-chemotype of U. tomentosa is a beneficial plant that they call savéntaro (saveshi=plant, antearo=potent). In nature, Cat's Claw occurs in two distinct chemical compositions: one containing beneficial pentacyclic oxindole alkaloids (POAs), and another containing tetracyclic oxindole alkaloids (TOAs), which can have undesirable health effects. Saventaro is harvested from rootstock and uses a patented extraction method that guarantees it contains only POAs, which possess clinically demonstrated immune-modulating properties.† Saventaro is analyzed and lab certified by high performance liquid chromatography (HPLC) to be free of harmful levels of tetracyclic oxindole alkaloids (TOAs).
What is monolaurin?
Monolaurin is a fatty acid found in human and coconut milk. It enhances immune defenses against foreign matter and supports healthy micorflora balance.†
At what age can ImmunoKids® be taken?
The Learner's Edge line of products was developed to meet the nutritional needs of school-aged children (five years of age or older).† While we know of no specific contraindications against the use of ImmunoKids® in younger children, the product has not been tested in this sub-set. Therefore, we urge parents interested in giving ImmunoKids® to younger children to discuss it with the child's physician prior to use.
Are any ingredients in ImmunoKids® derived from nuts?
No, none of the ingredients in ImmunoKids® are derived from nuts. By law, dietary supplement manufacturers must clearly list any and all ingredients obtained from peanuts and tree nuts, as well as the other Top 8 Allergens.
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