Overview

Why IP-6 and Inositol for deep immune support?†
It naturally boosts the body's defenses:†

IP-6, found in the bran of brown rice, and inositol, part of the vitamin B family, both help support the immune system.†

Why Cell Fortè^® IP-6 & Inositol?
It provides powerful protection:†

If you're serious about defending your immune health at a cellular level, this patented formula:†

• Boosts the body's natural defenses.†
• Enhances healthy cell growth.†
• Dramatically increases natural killer cell activity.†

Maximum effectiveness:†

It boosts the body's natural cellular defenses by increasing levels of inositol phosphates in your cells to help strengthen and enhance your immune system.†

Proven results:†

IP-6 and Inositol, as found in Cell Forté, delivers serious deep immune support and have been scientifically proven to increase natural killer cell activity by 58%.†**

**Compared to the control group.

Directions

Chew one tablet twice daily. Best taken on an empty stomach. Up to eight tablets may be taken daily for superior support.

Pill Size

Interactions and Depletions

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Technical Data

Description

Cellular Forté^® with IP-6 and Inositol, is a patented (United States Patent Number 5,082,833) combination of inositol hexaphosphate (IP-6 or phytate) and inositol with a unique 1:1 molecular ratio.¹

How Does It Work?

Cellular Forté^® with IP-6 and Inositol provides nutritional support of immune function including healthy cell development and natural killer cell activity.†

Healthy Cell Development
Healthy cells are characterized by structural and organizational integrity. They have a cytoskeleton composed of bundles of proteins that provide the structure and shape of the cell. Distinct structure and function is an important component in healthy cell development. Healthy cells differentiate from other cells, with disparate and distinct potential for cell development.^1-3

Healthy cells have cell membranes with complex coverings that determine what molecules can enter and leave the cell. Healthy cell surface function is vital to healthy cell development. A number of biochemical substances are present on cell surfaces and allow healthy cell interaction with other healthy cells. Healthy cells develop from intact and functioning genetic material.^1-3

Natural Killer Cells
Natural killer (NK) cells are a subset of peripheral blood lymphocytes. In contrast to other lymphocytes, NK cells do not require communication with other immune cells prior to activity. NK cells mediate a variety of important healthy immune system functions, including overall surveillance and healthy immunoregulation. Increases in healthy NK cell activity provide support of healthy immune function.^4,5

Inositol Hexaphosphate
Inositol hexaphosphate (IP-6 or phytic acid) is an inositol molecule with six phosphate groups attached. Inositol hexaphosphate is ubiquitous (found everywhere) in the plant kingdom and abundant in cereals and legumes.^6,7 In smaller amounts, IP-6 is contained in most mammalian cells, where it supports cellular functions.†^8-14 In addition, IP-6 functions as an antioxidant.†^15,16

Inositol
Inositol is a water soluble, ubiquitous 6-carbon sugar. Recognized as part of the vitamin B complex group, inositol is an important dietary and cellular constituent. Major food sources include beans, citrus fruit, nuts, rice, veal, pork, and wheat germ.¹⁷ Inositol supports healthy nerve transmission, healthy fat metabolism, and is needed for cell membrane structure and integrity.†^18-23

Inositol Hexaphosphate and Inositol
While independently these molecules support immune health, the unique combination of IP-6 and inositol functions synergistically.† Research indicates the combination of IP-6 and inositol supports stronger healthy cell development and increased natural killer cell activity as opposed to either compound alone.†^24-26

Through phosphorylation, inositol molecules can accept up to six phosphate groups. Lower inositol phosphates (IP-1, IP-2, IP-3, and IP-4) act as cellular messengers with varying degrees of activity.²⁷ IP-3, a highly active molecule, has numerous cellular supportive and cellular communication functions.²⁸

Inositol hexaphosphate is hypothesized to support healthy cellular function through dephosphorylation into IP-3.† When inositol is combined with IP-6, it can accept the phosphates that are liberated from the breakdown of IP-6, thereby increasing the intracellular levels of beneficial IP-3 molecules.^24-26 Research suggests that IP-6, and its lower phosphorylated, forms help support healthy cell development.†^26-28

Both the molecular ratio and the weight ratio of IP-6 to inositol are important in Cellular Forté^® with IP-6 and Inositol:

	Molecular Ratio	Weight
IP-6	1	400 mg
Inositol	1	110 mg

One molecule of IP-6 is four times the weight of an inositol molecule. A 1:1 molecular ratio, the ratio that yields maximum IP-3 production, is obtained by combining 400 mg IP-6 to 110 mg of inositol. Any variance from this 1:1 molecular ratio results in a significant reduction of IP-3 molecules produced.1 It is the molecular ratio, unique to the patent that distinguishes Cellular Forté^® with IP-6 and Inositol from other products. Therefore, no other product can yield the optimal amount of IP-3 that Cellular Forté^® with IP-6 and Inositol can deliver.

Recommendations

Chew one tablet twice daily. Best taken on an empty stomach. Up to eight tablets may be taken daily for superior support.

Precautions

Inositol hexaphosphate bound to protein in bran or fiber is absorbed more slowly than pure IP-6. Some research has demonstrated that bound IP-6 may interact and potentially bind with minerals in the stomach.¹⁰ Because of this potential interaction, it is recommended to take Cellular Forté® with IP-6 and Inositol on an empty stomach (1/2 hour before or 2 hours after meals).

How Is It Supplied?

• 05826;60 Chewable Tablets

Storage Recommendations

Store at controlled room temperature, 59° to 86°F (15°-30°C)

References

1. US Patent and Trademark Office. Patent number 5,082,833; Inventor: Abulkalam M. Shamsuddin; patent date: January 21, 1992.
2. LeMarbre PJ, Groenwald SL. Biology of cancer. In: Groenwald SL, Hansen Frogge M, Goodman M, Henke Yarbo C. Cancer Nursing: Principles and Practice. 4th ed. Sudbury, Ma: Jones and Bartlett; 1997: 17-26.
3. Guyton AC, Hall JE. Control of genetic function and biochemical activity in cells. Textbook of Medical Physiology. 10th Ed. Philadelphia, Pa: W.B. Saunders Company; 2000: 30-37
4. Porth CM, Carroll EW. Functional components of the cell. In: Porth CM. Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 1998: 3-12.
5. Guyton AC, Hall JE. Innate immunity. Textbook of Medical Physiology. 10th Ed. Philadelphia, Pa: W.B. Saunders Company; 2000: 402.
6. Sommers C. Natural killer cells. In: Porth CM. Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 1998:197-198.
7. Jariwalla RJ.Rice-bran products: phytonutrients with potential applications in preventive and clinical medicine. Drugs Exp Clin Res. 2001;27:17-26.
8. Shamsuddin AM. Metabolism and cellular functions of IP6: a review. Anticancer Res. 1999;19:3733-3736.
9. Jariwalla RJ. Inositol hexaphosphate (IP6) as an anti-neoplastic and lipid-lowering agent. Anticancer Res. 1999;19:3699-3702.
10. Shamsuddin AM, Vucenik I. Mammary tumor inhibition by IP6: a review. Anticancer Res. 1999;19:3671-3674.
11. Ishikawa T, Nakatsuru Y, Zarkovic M, Shamsuddin AM. Inhibition of skin cancer by IP6 in vivo: initiation-promotion model. Anticancer Res. 1999;19:3749-3752.
12. Vucenik I, Tantivejkul K, Zhang ZS, Cole KE, Saied I, Shamsuddin AM. IP6 in treatment of liver cancer. I. IP6 inhibits growth and reverses transformed phenotype in HepG2 human liver cancer cell line. Anticancer Res. 1998;18:4083-4090.
13. Vucenik I, Zhang ZS, Shamsuddin AM. IP6 in treatment of liver cancer. II. Intra-tumoral injection of IP6 regresses pre-existing human liver cancer xenotransplanted in nude mice. Anticancer Res. 1998;18:4091-4096.
14. Vucenik I, Kalebic T, Tantivejkul K, Shamsuddin AM. Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res. 1998;18:1377-1384.
15. Yang GY, Shamsuddin AM. IP6-induced growth inhibition and differentiation of HT-29 human colon cancer cells: involvement of intracellular inositol phosphates. Anticancer Res. 1995;15:2479-2487.
16. Johnson M, Tucci M, Benghuzzi H, Cason Z, Hughes J. The effects of inositol hexaphosphate on the inflammatory response in transformed RAW 264.7 macrophages. Biomed Sci Instrum. 2000;36:21-26.
Zhou JR, Erdman JW Jr. Phytic acid in health and disease. Crit Rev Food Sci Nutr. 1995;35:495-508.
18. Holub BJ. The nutritional significance, metabolism, and function of myo-inositol and phosphatidylinositol in health and disease. Adv Nutr Res. 1982;4:107-141.
19. Colodny L, Hoffman RL. Inositol--clinical applications for exogenous use. Altern Med Rev. 1998;3:432-447.
20. Gordon PR, Mawhinney TP, Gilchrest BA. Inositol is a required nutrient for keratinocyte growth. J Cell Physiol. 1988;135:416-424.
21. Downes CP, Macphee CH. Myo-inositol metabolites as cellular signals. Eur J Biochem. 1990;193:1-18.
22. Sun XY, Edvinsson L, Yoo H, Wahlestedt C, Hedner T. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. J Cardiovasc Pharmacol. 1995;25:696-704.
23. Payrastre B, Missy K, Giuriato S, Bodin S, Plantavid M, Gratacap M. Phosphoinositides: key players in cell signalling, in time and space. Cell Signal. 2001;13:377-87.
24. Tuersley MD, Best L, Tomlinson S. Inositol uptake and metabolism in neuronal tissue. J Neurochem. 1988;51:1610-1616.
25. Shamsuddin AM, Ullah A, Chakravarthy AK. Inositol and inositol hexaphosphate suppress cell proliferation and tumor formation in CD-1 mice. Carcinogenesis. 1989;10:1461-1463.
26. Vucenik I, Yang GY, Shamsuddin AM.Inositol hexaphosphate and inositol inhibit DMBA-induced rat mammary cancer. Carcinogenesis. 1995;16:1055-1058.
27. Shamsuddin AM. IP6: An anticancer cocktail: IP-6 and inositol. In: IP6: Nature's Revolutionary Cancer Fighter. New York: Kensington Publishing Corp; 1998:115-121.
28. 28. Weaver CM, Heaney RP. Intracellular messengers. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999: 148-148.
29. Jones PJH, Kubow S. Membrane functions and integrity. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999: 84.

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