Overview
Why support a healthy liver with supplements?
The liver has a tough job:†
It detoxifies the body by filtering out toxins from the blood; helps produce and secrete bile; and it helps the body metabolize carbohydrates, fats, and proteins.
Why take Liv-A-Tox®?
It provides vitamins, herbs and other nutrients to help your liver work at its best:†
Not your "every day" liver support supplement, Liv-A-Tox® is meant to be used periodically to help your liver increase bile production and purge the body of toxins.† After all, optimum liver function depends on adequate bile flow and healthy enzyme systems.†
Taken with Super Milk Thistle, it provides even more support:†
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Technical Data
Description
Liv-A-Tox® is a nutritional supplement that provides superior support of liver health.
A highly complex and metabolically active organ, most of the liver's physiologic functions fall within three main categories:
- Detoxification and filtration,
- Bile production and secretion,
- Metabolism and enzymatic activity.1
While the nutrients in Liv-A-Tox have been studied for their specific support of each category, many provide broad support and work together to ensure overall liver health. Liv-A-Tox is a potent formula designed for periodic use to purge the body of toxins, help increase bile production, and provide targeted support of the liver's enzymatic and metabolic pathways.
Introduction
Throughout all of history, the liver has been recognized for its important role in human health. In ancient Rome, the physician Galen thought that the liver was the principal organ of the human body, arguing that its large, moist nature kept the internal anatomical structures warm. For centuries it was thought that blood was made in the liver due to its extensive vasculature. In 1653, the English physician William Harvey spoke of the liver as a "noble organ" in his
Lectures on the Whole of Anatomy.2
For thousands of years it was thought that the liver and human emotions were connected. The word melancholy is from the Greek melankholia, from melas 'black' + khole 'bile', an excess of which was believed to cause feelings of sadness. 2 However, to Berber clans living in Morocco, the liver is considered to be the organ of romance and true love. In Berber cultures young persons in love promise their livers, not their hearts to one another, and speak of their “livers melting, being captured, and stolen” when they find true love.3
How Does It Work?
The human liver is the largest internal organ. About the size of a football, the average adult's liver weighs 3.5 pounds. The entire blood supply passes through the liver many times daily for detoxification and filtration of wastes. Bile, a complex biochemical mixture, is made continuously by the liver to aid in fat digestion. The liver has numerous enzymatic pathways that where drugs, toxins, nutrients, and physiologic byproducts are metabolized and eventually eliminated from the body.
1 The chart below provides information on each nutrient in
Liv-A-Tox.
| Ingredient | Functional Category | Benefit to Liver Health |
| Vitamin A |
Bile production |
Supports healthy liver cells; promotes immune health within liver tissues, plays role in bile production. 4-7 |
| Vitamin C |
Detoxification |
An important antioxidant, especially in liver health.8 Recent clinical studies have demonstrated that within cellular structures of the liver vitamin C supports hepatocyte (liver cell) health and supports liver function during detoxification. 9-11 |
| Niacin |
Metabolism |
As one of several bile acid sequestrants, niacin is preferred due to its support of healthy triglyceride levels that are already healthy. 12-14A recent meta-analysis of niacin that included a long-term outcome study of 2,248 men, found that niacin supports healthy cholesterol production in the liver.15 |
| Vitamin B12 |
Detoxification |
Unique among the water soluble vitamins, B12 can be stored in the liver. Healthy vitamin B12 levels are an indication of healthy liver function.16-18 |
| Biotin |
Metabolism |
In addition to being a vital cofactor to several enzymes, biotin is essential in carbohydrate metabolism and the synthesis of fatty acids.19 Clinical research has demonstrated that biotin supports healthy bile production.20-21 |
| Choline Bitartrate |
Metabolism |
Choline is necessary for the transport of lipids. Clinical research has demonstrated the importance of choline to liver health. 22-24 |
| L-Methionine |
Metabolism |
Provides support for normal fat metabolism. 25,26 |
| Barberry (Berberis vulgaris) and Boldo |
Bile secretion |
Both barberry and boldo help to increase bile flow, support liver health, and encourage overall detoxification. 27,28 |
| Fringe Tree (Chionanthus virginicus) Bark |
Bile production |
The bark of the fringe tree helps increase the production of bile and supports healthy fluid balance and acts as a gentle laxative. 29 |
| Betaine HCL |
Detoxification |
Higher intakes of dietary betaine are related to lower homocysteine concentrations independent of other determinants, including folate and other B vitamins.
Betaine has been found to protect liver cells from toxins.30,31
|
| Choline |
Metabolism
|
Because this vitamin supports fat metabolism in the liver and maintains healthy cholesterol levels in the bloodstream that are already within normal limits, choline may be especially beneficial for people who drink alcohol.22 |
| Celandine (Chelidonium majus) Ox Bile Extract
Beet (Beta vulgaris) Root Inositol
Liver (desiccated)
Evening Primrose (Oenothera biennis)
|
Overall liver support |
This proprietary blend of specialized nutrients provides broad support of healthy enzymatic, metabolic, detoxification, filtration, bile production, and bile secretion.32-36 |
Conclusion
Liv-A-Tox provides a well-balanced combination of nutrients needed for healthy liver function. By supporting the three main physiologic functions, Liv-A-Tox helps the liver perform healthy detoxification processes, optimal bile production and secretion, effective nutrient metabolism, and vital enzymatic activity.
Recommendations
Three tablets daily.
Precautions
If you are pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
How Is It Supplied?
Storage Recommendations
Store at controlled room temperature, 59° to 86°F (15° – 30°C).
References
- Guyton AC, Hall JE. Hepatobiliary function. In: Textbook of Medical Physiology.11th Ed. Philadelphia, Pa: W.B. Saunders Company; 2005:673-681.
- History of the Liver, Spleen, and Gall Bladder. Early Science Lab, Department of the Humanities, Stanford University. Accessed on December 10, 2007. Available at:http://www.stanford.edu/class/history13/earlysciencelab/body/liverpages/livergallbladderspleen.html
- Courtney-Clark M . Imazighen: The Vanishing Traditions of Berber Women. New York, NY: Clarkson Potter; 1995: 14-15.
- Takai K, Okuno M, Yasuda I, et al. Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma. Updated analysis of the long-term follow-up data. Intervirology. 2005;48:39-45.
- Dragnev KH, Petty WJ, Dmitrovsky E. Retinoid targets in cancer therapy and chemoprevention. Cancer Biol Ther. 2003;2:S150-6.
- Drozda R, Grzegorczyk K, Rutkowski M, Smigielski J, Kolomecki K. [The estimation of antioxidative vitamins concetrations in blood plasma of patients with neoplasms of gallblader and biliary tract] Pol Merkur Lekarski. 2007;131:391-4.
- Booth LA, Gilmore IT, Bilton RF. Secondary bile acid induced DNA damage in HT29 cells: are free radicals involved? Free Radic Res. 1997;26:135-44.
- Kojo S. Vitamin C: basic metabolism and its function as an index of oxidative stress. Curr Med Chem. 2004;11:1041-64.
- Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2003;98:2485-90.
- Gueguen S, Pirollet P, Leroy P,et al. Changes in serum retinol, alpha-tocopherol, vitamin C, carotenoids, zinc, and selenium after micronutrient supplementation during alcohol rehabilitation. J Am Coll Nutr. 2003;22:303-10.
- Vojdani A, Bazargan M, Vojdani E, Wright J. New evidence for antioxidant properties of vitamin C. Cancer Detect Prev. 2000;24:508-23.
- Sanyal S, Karas RH, Kuvin JT. Present-day uses of niacin: effects on lipid and non-lipid parameters. Expert Opin Pharmacother. 2007;8:1711-7.
- Mandeville WH, Arbeeny C. Bile acid sequestrants: their use in combination with other lipid-lowering agents. IDrugs. 1999;2:237-42.
- Bloomgarden ZT. 2nd International Symposium on Triglycerides and HDL: lipid abnormalities and their treatment. Diabetes Care. 2005;28:2795-802.
- Birjmohun RS, Hutten BA, Kastelein JJ, Stroes ES. Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials. J Am Coll Cardiol 2005;45:185-97.
- Halifeoglu I, Gur B, Aydin S, Ozturk A. Plasma trace elements, vitamin B12, folate, and homocysteine levels in cirrhotic patients compared to healthy controls. Biochemistry (Mosc). 2004;69:693-6.
- Ermens AA, Vlasveld LT, Lindemans J. Significance of elevated cobalamin (vitamin B12) levels in blood. Clin Biochem. 2003;36:585-90.
- Loew D, Wanitschke R, Schroedter A. Studies on vitamin B12 status in the elderly--prophylactic and therapeutic consequences. Int J Vitam Nutr Res. 1999;69:228-33.
- Fleming T., ed. Biotin. In: PDR® for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 27-28.
- Nagamine T, Saito S, Yamada S, Arai T, Takehara K, Fukui T. Biotinidase activity in patients with liver disease. Scand J Gastroenterol. 1993;28:899-906.
- Schulpis KH, Gavrili S, Tjamouranis J, Karikas GA, Kapiki A, Costalos C. The effect of neonatal jaundice on biotinidase activity. Early Hum Dev. 2003;72:15-24.
- Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. J Lipid Res. 2008 Jan 19; [Epub ahead of print]
- Chawla RK, Wolf DC, Kutner MH, Bonkovsky HL: Choline may be an essential nutrient in malnourished patients with cirrhosis. Gastroenterology 97: 1514–1520, 1989.
- Savendahl L, Mar MH, Underwood L, Zeisel S: Prolonged fasting results in diminished plasma choline concentration but does not cause liver dysfunction. Am J Clin Nutr 66: 622–625, 1997.
- Newberne PM, Suphiphat V, Locniskar M, de Camargo JL. Inhibition of hepatocarcinogenesis in mice by dietary methyl donors methionine and choline. Nutr Cancer. 1990;14(3-4):175-81.
- Kharbanda KK. Role of transmethylation reactions in alcoholic liver disease. World J Gastroenterol. 2007;13:4947-54.
- Arayne MS, Sultana N, Bahadur SS. The berberis story: Berberis vulgaris in therapeutics. Pak J Pharm Sci. 2007;20:83-92.
- Monograph. Berberine. Altern Med Rev. 2000;5:175-7.
- Gülçin I, Elias R, Gepdiremen E, Boyer L, Koksal E. A comparative study on the antioxidant activity of fringe tree (Chionanthus virginicus L.) extracts. Afr J Biotechnol. 2007;6:410-418.
- Kharbanda KK, Mailliard ME, Baldwin CR, Beckenhauer HC, Sorrell MF, Tuma DJ. Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J Hepatol. 2007;46:314-21.
- Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol. 1996;13:395-8.
- Biswas SJ, Bhattacharjee N, Khuda-Bukhsh AR. Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice. Food Chem Toxicol. 2007 Dec 15; [Epub ahead of print]
- Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Dig Liver Dis. 2007;39:293-304.
- Gaby AR. Natural remedies for scleroderma. Altern Med Rev. 2006;11:188-95.
- Puri BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). J Clin Pathol. 2007;60:122-4.
- Doster B. Senior Vice-President Research and Development. Personal communication. February 5, 2007.
Ingredients
| Amount/Serving | %DV |
|
Calories
|
10
|
|
|
|
Total Carbohydrate
|
2g
|
<1%**
|
|
|
Dietary Fiber
|
1g
|
4%**
|
|
|
Vitamin A (as retinyl acetate)
|
4,500IU
|
90%
|
|
|
Vitamin C (ascorbic acid and from rose hips)
|
25mg
|
42%
|
|
|
Niacin (as niacin and niacinamide)
|
40mg
|
200%
|
|
|
Vitamin B12 (as cyanocobalamin)
|
3 mcg
|
50%
|
|
|
Biotin
|
200 mcg
|
67%
|
|
|
Sodium
|
10 mg
|
<1%
|
|
|
Choline Bitartrate
|
850 mg
|
*
|
|
|
L-Methionine
|
250 mg
|
*
|
|
|
Barberry (Berberis vulgaris) Root Extract 6:1
|
150mg
|
*
|
|
|
Boldo (Peumus boldus)
|
150mg
|
*
|
|
|
Celandine (Chelidonium majus)
|
135mg
|
*
|
|
|
Fringe Tree (Chionanthus virginicus) Bark
|
135 mg
|
*
|
|
|
Ox Bile Extract
|
90mg
|
*
|
|
|
Beet (Beta vulgaris) Root Extract
|
75mg
|
*
|
|
|
Betaine HCl
|
75 mg
|
*
|
|
|
Inositol
|
50 mg
|
*
|
|
|
Liver (desiccated)
|
40 mg
|
*
|
|
|
Evening Primrose (Oenothera biennis)
|
30mg
|
*
|
|
This product does not contain
- artificial coloring
- artificial flavoring
- corn
- dairy products
- gluten
- preservatives
- sugar
- wheat
- yeast
This product contains natural ingredients; color variations are normal.
Notes
Lipotropic factors such as methionine and choline may provide support for normal fat metabolism.
All organs and glands derived from bovine sources.
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
**Based on 2000 calorie diet.Other Ingredients: cellulose, magnesium stearate, modified cellulose gum, stearic acid, modified cellulose, soy lecithin, and carnauba wax.
UPC Codes: 763948012596
Frequently Asked Questions
Why would I want to detoxify my liver?
Supporting the the liver is important as it has hundreds of functions in the body, including assisting in digestion and filtering toxins from the blood. The number of toxins that our livers must contend with has increased tremendously over the past century. Too many toxins and the liver can’t keep up and toxins are released into the body. Ingredients in Liv-A-Tox®, such as Barberry, Fringe Tree, and Boldo, help to increase bile flow, support liver health, and encourage overall detoxification.†
What’s bile?
Bile is a fluid made in the liver and stored in the gallbladder. Bile helps break down fats in the small intestines. Bile also is responsible for moving toxins to the intestines so they can be expelled from the body.
What is fringe tree?
Fringe tree is small tree with white flowers that is native to the eastern United States. The bark of the fringe tree helps increase the production of bile and supports healthy fluid balance and acts as a gentle laxative.†
Can I take Liv-A-Tox® long term?
Liv-A-Tox® is potent formula designed to provide targeted liver support and cleansing.† The formula is not meant to be taken all year long, but used periodically as a liver cleanse to help increase bile production and purge the body of toxins.† For daily, ongoing liver support, we suggest Super Milk Thistle®, which contains ingredients that help restore liver function.†
What is boldo?
Boldo is a type of tree that grows in South America. It has a very long history of traditional use for support of the liver and gallbladder, as well as promoting healthy fluid balance.† The leaves, which contain a compound called boldine, are considered the most beneficial part of the plant.†
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