Overview

Why cleanse?
Toxins are everywhere.

They're in our air, food and water - you can't escape them. Your digestive and overall health can be vulnerable to exposure to these environmental toxins.

Why use Whole Body Cleanse^™†?
It's convenient and easy.

Whole Body Cleanse^™† is a complete 3-product kit - everything you need for a safe, gentle 2-week cleanse.†

Whole Body Cleanse^™† eliminates toxins with fiber.†

Other products don't include fiber - but without it, toxins get reabsorbed in your system

Each supplement in the Cleanse has a purpose.

• To Cleanse: Super Milk Thistle^® supplement stimulates toxin-clearing bile flow.†
• To Detoxify: Fiber Fusion™ daily cleansing fiber binds to toxins so they don't get reabsorbed into your bloodstream.†
• To Rejuvenate: The Laxative Formula gently purges the intestines of built up toxins, makes sure the toxins are carried out of your body for thorough detoxification.†

Directions

Whole Body Cleanse^† Laxative Formula:
Day 1 through 7: three tablets at bedtime with 8 ounces of water
Day 8 through 14: two tablets at bedtime with 8 ounces of water.
Reduce dosage if you experience abdominal discomfort or diarrhea. If discomfort persists, discontinue use.

Fiber Fusion^™:
For 14 days, take four UltraCaps^™ in the morning and four at night with eight ounces of water. Or, may be taken as eight UltraCaps at night with eight ounces of water. For more information, see enclosed guide.

Super Milk Thistle^®:
Day 1 through day 7: One UltraCap^™ at night.
Day 8 through day 14: One UltraCap^™ in the morning and two at night.

Interactions and Depletions

Technical Data

Description

Whole Body Cleanse is a gentle, yet effective detoxification program, which provides three products in one easy-to-use kit.^† Super Milk Thistle^® liver cleansing formula stimulates bile flow and enhances the liver's detoxification processes, Fiber Fusion^™ daily cleansing fiber binds toxins and promotes digestive regularity, and Whole Body Cleanse Laxative Formula safely and gently promotes bowel movements to rid the body of toxins.^† The unique Whole Body Cleanse formulas provide support for the body's major detoxification organs: liver, intestines, blood, and lymph.^†

Whole Body Cleanse:

• Simple 2-week program
• Provides comprehensive cleansing of the gastrointestinal tract, liver, lymph and blood^†
• Contains no harsh stimulant laxatives
• Includes fiber featuring True Dispersion^™ Technology

Introduction

For thousands of years, detoxification practices have been used to cleanse the body of toxins and promote healthy digestion.^† Written health records from ancient Rome and Greece contain numerous references to the use of natural cleansing and purifying herbs.^† Tribal peoples almost universally have used indigenous plants and herbs to assist in eliminating toxins from the body.^† Well into the 19th century, cleansing practices continued to be used to improve human health.^†1 Over these many years of use, observations have repeatedly affirmed that cleansing affects not only the physical being, it influences mental, emotional, and spiritual health as well.^†2

How Does It Work?

Whole Body Cleanse contains three products in one kit to promote thorough detoxification.^† The combination provides support for all of the body's major detoxification organs, including the liver, intestines, blood, and lymph.^†

Super Milk Thistle^®
Super Milk Thistle provides support for liver function, and bile production and flow.^† The formula combines extracts of artichoke, dandelion leaf, and licorice root with milk thistle extract, standardized to contain 80 percent silymarin – milk thistle's most bioactive compound. A proprietary delivery system, known as the UltraCleanse, provides superior absorption of the milk thistle extract.^†

The following table details the benefits of the key ingredients in Super Milk Thistle:

Ingredient	Benefit
Milk Thistle	Milk Thistle supports healthy detoxification by enhancing bile flow and strengthening the liver at a cellular level.† The most bioactive compound in milk thistle is silymarin, a mixture of flavonoids with a long history of liver support.†3,4 Silymarin supports the health of Kupffer cells, specialized liver cells responsible for removing bacteria, old blood cells, and other foreign matter from the liver's blood supply.†3,4 Silymarin scavenges free radicals (superoxide anion radical and nitric oxide) produced by activated Kupffer cells, supports healthy leukotriene levels, and supports the production of glutathione, an antioxidant that is important for healthy detoxification.†3-5 Silymarin also supports the health of hepatocytes, highly versatile liver cells with unique physiologic functions.†3,4 Studies have demonstrated that silymarin enhances the health of the hepatocyte outer membrane, which is crucial to the liver's detoxification processes.†6 Silymarin also supports the healthy regenerative ability of the liver through support of protein synthesis in the hepatocytes.†7
Artichoke	Artichoke extract supports healthy bile production in the liver and promotes healthy gastrointestinal function.†8,9 Artichoke's gastrointestinal supportive properties have been documented in at least three clinical trials.†10-12
Dandelion	Like artichoke, dandelion root also supports healthy bile flow from the gallbladder.†13
Licorice	Licorice supports the healthy flow of bile and promotes immune system function.† Licorice also has a long history of providing healthy gastrointestinal support through the stimulation of natural protective factors and the support of healthy prostaglandin metabolism.†14,15

UltraCleanse
A special, proprietary process known as UltraCleanse, enhances the absorption of milk thistle in Super Milk Thistle^®.^† The process pairs herbal ingredients with phosphatidylcholine molecules. When milk thistle (or other herbs) are bound with phosphatidylcholine, the phosphatidylcholine molecules facilitate absorption through the intestines into the bloodstream.^† Research has shown increased blood and serum levels for bound herbs in comparison to the individual herb alone.^†16

Fiber Fusion^™
Fiber Fusion is a combination of all-natural fibers and herbs that safely absorbs and eliminates toxins and improves colon function.^† Fiber Fusion contains psyllium, one of the most preferred detoxification fibers. Psyllium supports cardiovascular, endocrine, and immune health, additional health benefits that other detoxification fibers often lack.^†17,18 Intestinal flora can also ferment psyllium into short-chain fatty acids (SCFA), supporting intestinal health and repair.^†19

While some psyllium products may not be thoroughly dispersed, Fiber Fusion utilizes patent-pending True Dispersion^™ technology to enhance its cleansing capabilities.^†

The following table summarizes the benefits of each of the ingredients in Fiber Fusion.

Ingredient	Benefit
Psyllium husk	Psyllium husk, a rich source of concentrated soluble fiber, that has been shown to absorb up to 14 times its weight in water and has more reabsorption ability than any other bowel-supporting fiber.†17 Psyllium husk supports healthy intestinal lubrication for ease in elimination.†20,21 Psyllium also supports cardiovascular, endocrine, and immune health, additional health benefits that other detoxification fibers often lack.†
Oat bran	The most soluble fiber of any grain, oat bran promotes bile production and forms a bulky gel in the intestine, which regulates the flow of excretory matter through the digestive tract.†22
Guar gum	Guar gum is a dietary fiber derived from the seed of the guar plant. Research shows that guar gum supports healthy digestive regularity.†23-25
Pectin	Derived from citrus fruits, pectin is a soluble fiber known for its adsorbent and bulk-forming properties.† Pectin is used to regulate bowel function, easing both occasional constipation and loose stools.†26
Marshmallow	Marshmallow root has been studied for its support of colon mucosa.† Because of its mucilaginous (moist, sticky) properties, marshmallow offers soothing support for the intestinal wall and helps facilitate comfortable elimination.†27

True Dispersion Technology
Fiber Fusion utilizes patent-pending True Dispersion Technology to ensure the psyllium, and other fibers, are completely released and dispersed in the colon for enhanced benefits.^† Unlike other psyllium supplements, which may not thoroughly disperse, this unique formulation will not clump. All components are fully released for optimum digestive results.^†28 No other psyllium fiber works as effectively as the psyllium in Fiber Fusion.

Whole Body Cleanse Laxative Formula^†
Whole Body Cleanse Laxative Formula works with Fiber Fusion^™ to bind toxins and thoroughly cleanse the intestines.^† Whole Body Cleanse Laxative Formula gently loosens built-up substances on the intestinal wall and enhances the transit time of intestinal substances.^†

Whole Body Cleanse Laxative Formula gently, but effectively cleanses the intestinal surfaces and promotes bowel function without the use of harsh, stimulant laxatives, such as senna and cascara.^† These laxatives chemically stimulate the intestines. If used on a routine basis, the bowels can become dependent on them and lose the built-in reflexes that normally help the bowels function. In contrast, Whole Body Cleanse Laxative Formula works with the body's own elimination processes to safely promote bowel movements.^† The formula also provides support for lymph and blood health, two health systems often bypassed in other detoxification laxative products. ^†

The following chart details the key benefits of the ingredients in Whole Body Cleanse Laxative Formula.

Ingredient	Benefit
Magnesium Hydroxide	Magnesium hydroxide is an osmotic laxative that draws water into the intestinal lumen.† Fecal matter inside the intestines softens and swells, which stretches the intestinal wall and stimulates peristalsis.† Research has shown that magnesium hydroxide increases the number of bowel movements, increases percentage of stool water, and increases stool volume.†29-31 The safety of magnesium hydroxide has been well established.31
Mucilage Blend: marshmallow, slippery elm, fenugreek	Slippery elm bark has antioxidant effects and has been studied for its support of bowel health.† The texture of slippery elm bark is mucilaginous, making it an excellent colon demulcent and emollient.†32 Marshmallow root has been studied for its support of colon mucosa.†33 Fenugreek seeds contain approximately 40 percent of mucilage fibers. Fenugreek has been studied for its support of gastrointestinal health.†34,35
Burdock	Burdock root supports the physiologic processes of organs involved in detoxification and elimination: the liver, kidneys, and intestines.†36,37 Due in part to these supportive effects, burdock has been used in the support of blood and blood constituent health.†36
Soothing Blend: fennel, ginger, peppermint	Peppermint leaf supports healthy relaxation of intestinal muscles and supports healthy bile flow.†38,39 Use of peppermint has been clinically studied for its support of gastrointestinal motility and support of healthy balanced intestinal flora.†40,41 Fennel seed also has gastrointestinal motility supportive properties.†42 A recent study demonstrated fennel supports healthy relaxation of the intestinal walls.†43 Studies have demonstrated that ginger supports healthy intestinal tone, healthy peristalsis, and healthy secretion of gastrointestinal fluids.†44,45
Red Clover	One of the most effective dietary supplements for lymph support is red clover.† It has been studied for its antioxidant activity and support of cardiovascular health.† Red clover extract supports liver health and support of healthy bile stimulation and production.†46,47

Conclusion
Whole Body Cleanse provides comprehensive detoxification support in a unique three-product kit.^† The combination of Super Milk Thistle^® liver cleansing formula, Fiber Fusion^™ daily cleansing fiber, and Whole Body Cleanse Laxative Formula enhances liver detoxification processes, increases toxin-binding abilities, and promotes bowel movements to rid the body of toxins.^† Whole Body Cleanse offers a gentle, yet effective alternative to other cleansing programs.^†

Recommendations

Whole Body Cleanse^† Laxative Formula:
Day 1 through 7: three tablets at bedtime with 8 ounces of water
Day 8 through 14: two tablets at bedtime with 8 ounces of water.
Reduce dosage if you experience abdominal discomfort or diarrhea. If discomfort persists, discontinue use.
Fiber Fusion^™:
For 14 days, take four UltraCaps^™ in the morning and four at night with eight ounces of water. Or, may be taken as eight UltraCaps at night with eight ounces of water. For more information, see enclosed guide.
Super Milk Thistle^®:
Day 1 through day 7: One UltraCap^™ at night.
Day 8 through day 14: One UltraCap^™ in the morning and two at night.

Precautions

Consult a healthcare practitioner before using any laxative if a sudden change in bowel habits occurs and persists for two weeks. Rectal bleeding or failure to have a bowel movement after use of a laxative may indicate a serious condition; discontinue use and consult a healthcare practitioner. Do not use if pregnant or nursing. Unless directed by a healthcare practitioner, do not use laxative products when abdominal pain, nausea, or vomiting is present, or if you have kidney disease. Do not take more than three tablets in a 24-hour period or use the maximum dosage for more than two weeks. If taking prescription drugs, consult your healthcare practitioner prior to use.

How Is It Supplied?

• 08450; 1 Kit containing:
• Whole Body Laxative Formula^†; 35 tablets
• Fiber Fusion^™ daily cleansing fiber^†; 112 UltraCaps^™
• Super Milk Thistle^® liver cleansing formula^†; 28 UltraCaps^™

Storage Recommendations

Store at controlled room temperature, 59° to 86°F (15° – 30°C).

References

1. Nick GL. The history of cleansing. In: Clinical Purification: A Complete Treatment and Reference Manual. Brookfield, Wis: Longevity Through Prevention Books; 2001: 7-10.
2. Haas EM, Levin B. Staying Healthy With Nutrition, 21st Century Edition: The Complete Guide to Diet & Nutritional Medicine. Berkeley, Calif: Celestial Arts; 2006: 157-187.
3. Milk thistle. In: Fleming T., ed. PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 516-520.
4. Milk thistle fruit. In: Blumenthal M, Goldberg A, Brinckmann J., ed. Herbal Medicine. Expanded Commission E Monographs. Austin, Tex: American Botanical Council; Integrative Medicine Communications; 2000: 257-263.
5. Dehmlow C, Erhard J, de Groot H. Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin. Hepatology. 1996;23:749-54.
6. Gonzalez-Correa JA, de la Cruz JP, Gordillo J, Urena I, Redondo L, Sanchez de la Cuesta F. Effects of silymarin MZ-80 on hepatic oxidative stress in rats with biliary obstruction. Pharmacology. 2002;64:18-27.
7. Dvorak Z, Kosina P, Walterova D, Simanek V, Bachleda P, Ulrichova J. Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum. Toxicol Lett. 2003;137:201-12.
8. Artichoke leaf. In: Blumenthal M, Goldberg A, Brinckmann J., ed. Herbal Medicine. Expanded Commission E Monographs. Austin, Tex: American Botanical Council; Integrative Medicine Communications; 2000:10-12.
9. Artichoke In: Fleming T., ed. PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 44-46.
10. Marakis G, Walker AF, Middleton RW, Booth JC, Wright J, Pike DJ. Artichoke leaf extract reduces mild dyspepsia in an open study. Phytomedicine. 2002;9:694-9.
11. Pittler MH, Thompson CO, Ernst E. Artichoke leaf extract for treating hypercholesterolaemia. Cochrane Database Syst Rev. 2002;:CD003335.
12. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res. 2001;15:58-61.
13. Dandelion root with herb. In: Blumenthal M, Goldberg A, Brinckmann J., ed. Herbal Medicine. Expanded Commission E Monographs. Austin, Tex: American Botanical Council; Integrative Medicine Communications; 2000: 81-83.
14. Licorice. In: Fleming T., ed. PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 469-474.
15. Licorice. In: Blumenthal M, Goldberg A, Brinckmann J., ed. Herbal Medicine. Expanded Commission E Monographs. Austin, Tex: American Botanical Council; Integrative Medicine Communications; 2000: 233-239.
16. Barzaghi N, Crema F, Gatti G, Pifferi G, Perucca E. Pharmacokinetic studies on IdB 1016, a silybin-phosphatidylcholine complex, in healthy human subjects. Eur J Drug Metab Pharmacokinet. 1990;15:333-338.
17. Nick GL. Psylium. In: Clinical Purification: A Complete Treatment and Reference Manual. Brookfield, Wis: Longevity Through Prevention Books; 2001: 183-190.
18. Jenkins DJ, Kendall CW, Vuksan V, et al. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am J Clin Nutr. 2002;75:834-9.
19. Mortensen PB, Clausen MR, Bonnen H, Hove H, Holtug K. Colonic fermentation of ispaghula, wheat bran, glucose, and albumin to short-chain fatty acids and ammonia evaluated in vitro in 50 subjects. JPEN J Parenter Enteral Nutr. 1992;16:433-9.
20. Leng-Peschlow E. Plantago ovata seeds as dietary fibre supplement: physiological and metabolic effect in rats. Br J Nutr.1991 Sep;66(2):331-49.
21. Marlett JA, Kajs TM, Fischer MH. An unfermented gel component of psyllium seed husk promotes laxation as a lubricant in humans. Am J Clin Nutr. 2000;72:784-9.
22. Andersson M, et al. Oat bran stimulates bile acid synthesis within 8 h as measured by 7alpha-hydroxy-4-cholesten-3-one. Am J Clin Nutr. 2002 Nov;76(5):1111-6.
23. Fleming T., ed. Guar gum. In: PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 376.
24. Krishnaiah YS, Karthikeyan RS, Bhaskar P, Satyanarayana V. Bioavailability studies on guar gum-based three-layer matrix tablets of trimetazidine dihydrochloride in human volunteers. J Control Release. 2002;83:231-9.
25. Parisi GC, Zilli M, Miani MP, et al. High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG). Dig Dis Sci. 2002;47:1697-704.
26. Monograph. Modified citrus pectin. Altern Med Rev. 2000;5:573-5.
27. Fleming T., ed. Marshmallow. In: PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 505-506.
28. Study on the comparative dispersion of encapsulated fiber blends. Unpublished data. June 2003.
29. Lehne RA. Laxatives. In: Pharmacology for Nursing Care. 3rd ed. Philadelphia, Pa: W.B. Saunders; 1998:787-792.
30. Kinnunen O, Salokannel J. Comparison of the effects of magnesium hydroxide and a bulk laxative on lipids, carbohydrates, vitamins A and E, and minerals in geriatric hospital patients in the treatment of constipation. J Int Med Res. 1989;17:442-54.
31. Hansen CT, Sørensen M, Møller C, Ottesen B, Kehlet H. Effect of laxatives on gastrointestinal functional recovery in fast-track hysterectomy: a double-blind, placebo-controlled randomized study. Am J Obstet Gynecol. 2007 Apr;196(4):311.e1-7.
32. Fleming T., ed. Slippery elm. In: PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000:697.
33. Fleming T., ed. Marshmallow. In: PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000:505-506.
34. Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Therapeutic applications of fenugreek. Altern Med Rev. 2003;8:20-7.
35. Pandian RS, Anuradha CV, Viswanathan P. Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats. J Ethnopharmacol. 2002;81:393-7.
36. Nick GL. Burdock root. In: Clinical Purification: A Complete Treatment and Reference Manual. Brookfield, Wis: Longevity Through Prevention Books; 2001:155-162.
37. Lin CC, Lu JM, Yang JJ, Chuang SC, Ujiie T. Anti-inflammatory and radical scavenge effects of Arctium lappa. Am J Chin Med. 1996;24:127-37.
38. Fleming T., ed. Peppermint. In: PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 580-583.
39. Nair B. Final report on the safety assessment of Mentha Piperita (Peppermint) Oil, Mentha Piperita (Peppermint) Leaf Extract, Mentha Piperita (Peppermint) Leaf, and Mentha Piperita (Peppermint) Leaf Water. Int J Toxicol. 2001;3:61-73.
40. Micklefield G, Jung O, Greving I, May B. Effects of intraduodenal application of peppermint oil (WS(R) 1340) and caraway oil (WS(R) 1520) on gastroduodenal motility in healthy volunteers. Phytother Res. 2003;17:135-40.
41. Goerg KJ, Spilker T. Effect of peppermint oil and caraway oil on gastrointestinal motility in healthy volunteers: a pharmacodynamic study using simultaneous determination of gastric and gall-bladder emptying and orocaecal transit time. Aliment Pharmacol Ther. 2003;17:445-51.
42. Fleming T., ed. Fennel. In: PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 302-304.
43. Namavar Jahromi B, Tartifizadeh A, Khabnadideh S. Comparison of fennel and mefenamic acid for the treatment of primary dysmenorrhea. Int J Gynaecol Obstet. 2003;80:153-7.
44. Blumenthal M, Goldberg A, Brinckmann J., ed. Ginger root. In: Herbal Medicine. Expanded Commission E Monographs. Austin, Tex: American Botanical Council; Integrative Medicine Communications, 2000: 153-159.
45. Hashimoto K, Satoh K, Murata P, et al. Component of Zingiber officinale that improves the enhancement of small intestinal transport. Planta Med. 2002;68:936-9.
46. Fleming T., ed. Red clover. In: PDR^® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 633-634.
47. Nick GL. Red clover. In: Clinical Purification: A Complete Treatment and Reference Manual. Brookfield, Wis: Longevity Through Prevention Books; 2001:165-178.

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