Overview
Why use fresh garlic extract?
Fresh garlic is best!
Nearly every clinical trial showing garlic's support for heart health used fresh garlic extracts.† After all, allicin - the key, proven compound - is found in fresh, but not aged, garlic.
Why use Garlinase® Fresh?
It's closest to fresh garlic:
Garlinase® Fresh delivers 5,000 mcg of allicin, fresh garlic's most beneficial compound. Allicin acts as an antioxidant and helps support cardiovascular health.†
No garlic breath!
Unique, proprietary process ensures maximum absorption and freshness. Enteric-coated tablets reach the small intestine, so you get garlic where you need it, and avoid garlic breath.†
Convenience:
Take only 1 tablet per day!
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Technical Data
Description
Garlinase Fresh® is a once daily dietary supplement containing fresh garlic extract. Each
Garlinase Fresh® tablet provides the equivalent of 4,000 mg of fresh garlic, the amount recommended by the
German Commission E Monographs.
1 Formulated from a patented Swiss process,
Garlinase Fresh® delivers a minimum of 5,000 mcg of beneficial allicin and 11,000 mcg of alliin per tablet.
Garlinase Fresh®'S enteric coating ensures dissolution in the small intestine and maximum allicin production.†
How Does It Work?
Garlic Chemistry
Garlic contains many compounds that individually possess a wide range of beneficial effects. One of the most biologically active is allicin, which also provides garlic's distinct odor. However, allicin itself is not present in an intact garlic clove. It is formed when a clove is crushed, releasing the precursor alliin and the enzyme allinase, which then come together to form allicin. Several well designed, robust studies have demonstrated allicin's health supportive benefits.†
1-3
While allicin from fresh garlic has very high bioavailability,4 its strong odor can be problematic. Garlic odor is not merely present in breath after its consumption, it is also released through the pores of the skin, often persisting for hours or days afterwards.1,2
The compounds in garlic have variable stability. Allinase is easily inactivated by gastric acid and allicin is fairly unstable prior to absorption in the bloodstream.3-5 Therefore, it is crucial that alliin and allinase taken in dietary supplements are introduced into the body where they can effectively create allicin.†
Garlic Supplement Disparities
Currently, there are several types of garlic supplements, including garlic oil, garlic powder, and aged garlic extract (AGE) products. Garlic oil supplements do not contain allicin, only allicin-derived compounds that have little beneficial effects at normal levels of garlic consumption.6,7 Softgel or hard shell capsulated garlic powder supplements that contain alliin and allinase are destroyed by gastric acid before they can create allicin and have minimal health supportive activity.8-10
Aged garlic extract products purposefully do not contain allicin. Disregarding the abundance of evidence that demonstrates the significance of allicin, the manufacturers of AGE supplements claim that other compounds are responsible for garlic's health supportive properties.11 Some studies have demonstrated that AGE supplements may have limited benefit. However, because AGE manufacturers sponsored these studies and their findings have yet to be replicated, leading garlic researchers question the validity of these findings. To date, the scientific consensus contends that allicin obtained from enteric-coated garlic tablets provides the most significant health supportive benefit.12
Allicin Research
Several studies have demonstrated allicin's health supportive benefits. Allicin acts as an antioxidant13 and helps support cardiovascular health.13-18 Allicin supports healthy immune system function, including support of healthy immune cell activation.19-22 Allicin supports healthy gastrointestinal function, especially support of healthy gastrointestinal mucosal
lining.†23-25
Garlinase Fresh®
The patented Swiss process makes Garlinase Fresh® truly unique among garlic supplements. When Garlinase Fresh® tablets are swallowed, the enteric coating resists disintegration until it reaches the alkaline environment of the small intestine. There the Garlinase Fresh® tablet dissolves releasing alliin and allinase to form allicin, which is slowly released over a long period of time and absorbed into the bloodstream.26 The slow release of Garlinase Fresh® in the small intestine also provides the superior health benefits of fresh garlic, but without garlic's distinct, and sometimes offensive, odor.
Summary
Garlinase Fresh®'s formulation reflects the considerable evidence that allicin is the most biologically active garlic compound. Formulated from a patented Swiss process, Garlinase Fresh®'s enteric coating and ensures that optimal allicin formation occurs. Garlinase Fresh®'s unique slow delivery of allicin provides significant health supportive benefits.
Recommendations
One tablet daily with food. DO NOT CHEW OR CRUSH.
Precautions
Garlic has some anticoagulant, or blood clotting prevention activity. As a result, concomitant use of garlic supplements with prescription anticoagulants or similar substances might potentiate the blood thinning effect. However, the exact significance of this interaction has not been quantified.
How Is It Supplied?
- 08501;100 Enteric Coated Tablets
- 08503; 30 Enteric Coated Tablets
Storage Recommendations
Store at controlled room temperature, 59°F and 68°F (15° and 20°C).
References
- Blumenthal M, ed. Garlic (Allii sativi bulbous). In: The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. Austin, Tex: American Botanical Council; 1998: 134-135.
- Fleming T., ed. Garlic (Allium sativum). In: PDR® for Herbal Medicines. Montvale, NJ: Medical Economics Company; 2000: 327-331.
- Koch HP. Therapeutic Effects and Applications of Garlic and its Preparations. In: Garlic: The Science and Therapeutic Application of Allium sativum L. and Related Species. Koch HP, Lawson L. eds. Baltimore, Md: Williams and Wilkins; 1996:38,103,153-162.
- Lawson L, Wang J. The common metabolism of allicin and allicin-derived compounds in humans and allicin release from garlic compounds. Presentation at the American Herbal products Association International Garlic Symposium. August 1st, 2001.
- Krest I, Keusgen M. Stabilization and pharmaceutical use of alliinase. Pharmazie. 1999;54:289-93.
- Zhang XH, Lowe D, Giles P, Fell S, Connock MJ, Maslin DJ. Gender may influence the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. J Nutr.2001;131:1471-1478.
- Berthold HK, Sudhop T, von Bergmann K. Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: a randomized controlled trial. JAMA. 1998;17:1900-1902.
- Staba EJ, Lash L, Staba JE. A commentary on the effects of garlic extraction and formulation on product composition. J Nutr. 2001;131:1118S-1119S.
- Isaacsohn JL, Moser M, Stein EA, et al. Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial. Arch Intern Med. 1998;158:1189-1194.
- Spigelski D, Jones PJ. Efficacy of garlic supplementation in lowering serum cholesterol levels. Nutr Rev. 2001;59:236-241.
- Amagase H, Petesch BL, Matsuura H, Kasuga S, Itakura Y. Intake of garlic and its bioactive components. J Nutr. 2001;131:955S-62S.
- Amagase H, Block E, Bordia A, Lawson LD. The controversial issues surrounding allicin versus non-allicin containing products. Panel Discussion. Presentation at the American Herbal products Association International Garlic Symposium. August 1st, 2001.
- Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins.
Biochim Biophys Acta. 1998;1379:233-44.
- Das I, Khan NS, Sooranna SR. Nitric oxide synthase activation is a unique mechanism of garlic action. Biochem Soc Trans. 1995;23:136S.
- Kim-Park S, Ku DD. Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats. Clin Exp Pharmacol Physiol. 2000;27:780-6.
- Kannar D, Wattanapenpaiboon N, Savige GS, Wahlqvist ML. Hypocholesterolemic effects of an enteric-coated garlic supplement. J Am Coll Nutr. 2001;20:225-31.
- Koscielny J, Klussendorf D, Latza R, Schmitt R, Radtke H, Siegel G, et al. The antiatherosclerotic effect of Allium sativum. Atherosclerosis. 1999;144:237-259.
- Orekhov AN, Grunwald J. Effects of garlic on atherosclerosis. Nutrition. 1997;13:656-663.
- Josling P. Preventing the common cold with a garlic supplement: a double blind, placebo-controlled survey. Adv Ther. 2001;18:189-93.
- Milner JA. A historical perspective on garlic and cancer. J Nutr. 2001;131:1027-31.
- Salman H, Bergman M, Bessler H, Punsky I, Djaldetti M. Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. Int J Immunopharmacol. 1999;21:589-97.
- Tang Z, Sheng Z, Liu S, Jian X, Sun K, Yan M. The preventing function of garlic on experimental oral precancer and its effect on natural killer cells, T-lymphocytes and interleukin-2. Hunan I Ko Ta Hsueh Hsueh Pao. 1997;22:246-248.
- Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother. 1997;41:2286-8.
- Jonkers D, van den Broek E, van Dooren, et al. Antibacterial effect of garlic and omeprazole on Helicobacter pylori. J Antimicrob Chemother. 1999;43:837-9.
- Kockar C, Ozturk M, Bavbek N. Helicobacter pylori eradication with beta-carotene, ascorbic acid and allicin. Acta Medica (Hradec Kralove). 2001;44:97-100.
- Klemen H. Enzymatic Therapy Director of Quality Control Laboratory. In-house communication (electronic mail). November 5, 2002.
Ingredients
| Amount/Serving | %DV |
|
Garlic (Allium sativum) Bulb Extract
|
320mg
|
*
|
|
This product does not contain
- artificial flavoring
- corn
- dairy products
- gluten
- ingredients of animal origin
- preservatives
- salt
- soy
- sugar
- wheat
- yeast
All colors used are from natural sources.
Notes
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
Support healthy cholesterol, naturally.† Maintains healthy cholesterol levels that are already within the normal range.†
This product has a tamper-evident blister sheet. Do not use if foil or plastic is punctured!
**The worldwide recognized authority for effective herbal remedies.
***SPINs Garlic Ingredient Report; 52 wks ending 7/12/08; Natural Product Smkt Channel; ttl US.
Other Ingredients: cellulose, modified cellulose, modified cellulose gum, silicon dioxide, titanium dioxide color, calcium stearate, fractionated coconut oil, sodium alginate, vegetable glycerin, and stearic acid.
UPC Codes: 763948085033
Frequently Asked Questions
What else can I take to support healthy cholesterol levels already within normal limits?†
For individuals looking to boost good cholesterol levels, we recommend HDL Booster ®†. HDL Booster® has been clinically shown to increase good cholesterol (HDL) levels by up to 23%.†
What’s the difference between aged versus fresh garlic?
Aged and fresh garlic extracts are processed very differently and contain different components. To make aged garlic, garlic is placed in an ethanol solution and stored for 20 months. Aged garlic extract contains S-allyl mercaptocysteine (SAMC), a compound that AGE makers claim is the reason garlic is so good for us. Interestingly, fresh garlic does not contain any SAMC. It only appears after the aging process. Although a body of research has been developed for aged garlic, there have been no successful independent replications of aged garlic studies.
Allicin is the key proven compound found in fresh, not aged, garlic. Allicin is a complex compound that is only released when a garlic clove is crushed (that’s what you smell when you mince garlic). Allicin acts as an antioxidant, helps support cardiovascular health, and supports the immune system.† Aged garlic yields no beneficial allicin.
Is Garlinase® Fresh enteric coated? Why does it matter?
Yes, Garlinase® Fresh is enteric coated. An enteric-coated product utilizes a protective outer layer to keep the beneficial garlic extract contained until it reaches the alkaline environment of the small intestine.† There, the tablet dissolves, slowly releasing alliin and allinase to form allicin, which is absorbed into the bloodstream as it travels slowly through the small intestine.†
Garlinase® Fresh also uses the combination of a special formulation and the enteric coating to keep the key components of garlic’s active ingredient, allicin, separate until they are released and combined in the small intestine. This ensures optimal absorption and reduces the odor often associated with garlic.
Why do I only have to take one tablet of Garlinase® Fresh per day?
There’s a lot of goodness in one small tablet. Garlinase® Fresh contains the equivalent of 4,000 mg of fresh garlic-the amount recommended by the German Commission E Monographs. One tablet of Garlinase® Fresh provides the allicin potential of four cloves of fresh garlic.
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