Overview

Why use a supplement to support lean body mass and weight training?
Because it can provide a safe alternative:†

With ingredients that balance testosterone naturally, you can maintain healthy fat metabolism and highlight muscle definition by building lean muscle mass without worry.†

Why use Pure Rip^™ with DIM^®?
It boosts the body's response to weight training:†

Maintaining the right balance of testosterone can maximize your body's response to weight training.†

Because of the hormone balancing benefits of Pure Rip^™ with DIM^®, you'll get more out of your strength training and bodybuilding programs - more support for increased lean muscle and improved physical conditioning.†

Directions

One tablet daily with food. If extra support is required, take two tablets with food.

Pill Size

Interactions and Depletions

Technical Data

Description

Pure Rip™ with DIM contains DIM (diindolylmethane), a naturally occurring phytochemical found in cruciferous vegetables. The DIM in Pure Rip™ with DIM is formulated with a patented technology enhancing its absorption and bioavailability. The role of DIM in the human body is to support healthy estrogen metabolism and hormonal balance.† While most frequently associated with female reproductive health, estrogen also has reproductive functions in men. If estrogen is not metabolized in balance with other male hormones, increased estrogen levels may result.

In weight training and bodybuilding programs, use of Pure Pure Rip™ with DIM may result in improved outcomes.† Pure Rip™ with DIM promotes the metabolism of estrogen, which in turn increases levels of testosterone, the primary male reproductive hormone.† High levels of testosterone and low levels of estrogen in men have been linked to lean body mass, an efficient fat-burning metabolism, and decreased abdominal obesity. Pure Rip™ with DIM creates a healthy hormonal balance for successful weight training and bodybuilding programs.†

How Does It Work?

Hormonal Influence on Weight Training
Successful systematic training and exercising to increase muscle mass is mediated by several factors. Individual genetic propensities, the strength and intensity of training, continuity and dedication, and guidance from certified fitness trainers are all associated with increased positive outcomes.^1-4 Nutritional support in muscle mass building and muscle definition is becoming increasingly sophisticated as ongoing clinical and in vitro research provides improved knowledge and understanding.^5,6 Evidence-based results are also clarifying the need for specific nutritional supplements in weight training.^7,8 Recently, the secretion and metabolism of endogenous sex hormones have been studied for their role in optimal outcomes in bodybuilding. ^9-11

Endogenous androgens are the male sex hormones responsible for male body musculature. Testosterone, the most abundant male sex hormone, promotes protein metabolism, musculoskeletal growth, and influences subcutaneous fat distribution in men.¹² From puberty on, men have twice the muscle mass of women due to the influence of testosterone.¹³

While estrogen is most frequently associated with the female reproductive system, endogenous estrogen is also produced in men and needed most notably for healthy sperm production.¹⁴ Just as there is more than one androgen, there are several estrogens. In addition to the main circulating estrogens (estradiol, estrone, and estriol), there are estrogen metabolites that occur with hormonal breakdown and metabolism.¹³

Estrogen metabolism is exceedingly complex, taking place primarily in the liver through specific enzymatic pathways. ^12,13 Metabolism occurring via the C-2 pathway increases the chances for estrogen to be broken down into 2-hydroxyestrone (2-OH1) and 2-hydroxyestradiol (2-OH2), estrogen metabolites known for their health supporting activities.†^15-18 Once 2-OH1 and 2-OH2 are present in the circulation, further metabolism results in 2-methoxyestrone and 2-methoxyestradiol. These critical metabolites have been shown to promote healthy cell development in animals and humans.†^19-23

In contrast, when a large proportion of estrogen is metabolized via the C-16 pathway, it is broken down into the16-hydroyestrone (16-OH) metabolites. This undesirable group of estrogen metabolites is associated with potentially harmful activities in the body, including the promotion of oxidation, damage to cellular DNA, and the promotion of unregulated cell growth. Increased amounts of harmful estrogen metabolites may result in an unhealthy ratio of harmful to beneficial metabolites, a biologic event known to influence several health concerns.†^24-26 Research has demonstrated that shifting estrogen metabolism to promote an increased 2-hydroxy to 16-hydroxyestrone ratio via the C-2 pathway may prove beneficial for a variety of conditions related to estrogen dominance or imbalance.†^27-29

Diindolylmethane and Hormonal Balance
For years, an observational association has been noted between healthy estrogen balance and a high dietary intake of vegetables, such as broccoli, cauliflower, and cabbage. Scientific study determined that such cruciferous vegetables contain several phytochemicals including indole-3-carbinol (I3C), phenethyl isothiocyanate (PEITC), sulforaphane, and diindolylmethane (DIM).^30,31 Further research has demonstrated that DIM is the most bioactive of these phytonutrients and the most effective in increasing beneficial estrogen metabolites and reducing undesirable estrogen metabolites.† ^32-35 While DIM cannot be absorbed adequately in its pure crystalline form due to its extreme insolubility in water, absorbable forms of pure DIM have been developed as dietary supplements using special absorption-enhancing formulas. ²⁷

Pure Rip™ with DIM and Weight Training/Bodybuilding
Improving estrogen metabolism with Pure Rip™ with DIM results in direct and indirect support for more efficient weight training.† Pure Rip™ with DIM contributes to a better metabolism by working with endogenous hormones and adjusting their action to avoid hormonal imbalance.† If active estrogen is eliminated by the beneficial metabolites, hormonal balance is further restored in men by the freeing of protein-bound testosterone.† The end result is a healthier balance of testosterone to estrogen and increased free testosterone circulating in the body.†²⁷ High levels of testosterone and low levels of estrogen in men have been linked to healthy body mass, healthy fat-burning metabolism, healthy abdominal fat distribution, and healthy libido.†^12,13

Bioavailability of DIM
It has been noted that dietary supplements containing other cruciferous phytochemicals, most notably I3C, claim to provide the same estrogen balancing benefits as DIM in Pure Rip™ with DIM. However, I3C is highly unstable and has no biologic activity until it is converted to DIM. Conversion of I3C takes place in the stomach and requires an appropriately acidic environment. In contrast to I3C, DIM is highly stable, requires no conversion in the stomach, and is the most active cruciferous phytonutrient in promoting beneficial estrogen metabolism.†³⁵

Though stable, the extreme water insolubility of DIM in its pure crystalline form requires an absorption enhancing delivery system for use in dietary supplements. Pure Pure Rip™ with DIM contains patented Indolplex® (Indolplex is licensed by BioResponse, L.L.C., under U.S. patent 6,086,915), long recognized for its superior DIM formulation. The Indolplex in Pure Rip™ with DIM contains microparticles of standardized DIM in a soluble matrix for enhanced absorption.²⁷

Conclusion
Improved hormonal balance is a critical key in helping men reach their fitness, strength training, and bodybuilding goals. Pure Rip™ with DIM contains pure DIM in a special absorption-enhancing formula, which provides the phytochemical in a consistent, bioavailable form, identical to the intake of DIM from the diet. Pure Rip™ with DIM supports estrogen metabolism that helps reduce harmful estrogen metabolites, while increasing levels of beneficial metabolites, leading to more circulating testosterone.† The hormone balancing benefits of Pure Rip™ with DIM in strength training and bodybuilding programs will result in the healthy support increased lean muscle mass and improved physical conditioning.†

Recommendations

One tablet daily with food. If extra support is required, take two tablets with food.

Precautions

Caution: Women should not use this product if pregnant or nursing. Harmless changes in urine color may occur with the use of this product.

How Is It Supplied?

• 05337;60 Tablets

Storage Recommendations

Store at controlled room temperature, 59° to 86°F (15°-30°C).

References

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2. Paavolainen L, Hakkinen K, Hamalainen I, Nummela A, Rusko H. Explosive-strength training improves 5-km running time by improving running economy and muscle power. Scand J Med Sci Sports. 2003;13:272.
3. Hoffman JR, Kang J. Strength changes during an in-season resistance-training program for football. J Strength Cond Res. 2003;17:109-14.
4. Blazevich AJ, Jenkins DG. Effect of the movement speed of resistance training exercises on sprint and strength performance in concurrently training elite junior sprinters. J Sports Sci. 2002;20:981-90.
5. Fielding RA, Parkington J. What are the dietary protein requirements of physically active individuals? New evidence on the effects of exercise on protein utilization during post-exercise recovery. Nutr Clin Care. 2002;5:191-6.
6. Too D, Wakayama EJ, Locati LL, Landwer GE. Effect of a precompetition bodybuilding diet and training regimen on body composition and blood chemistry. J Sports Med Phys Fitness. 1998;38:245-52.
7. Nissen S, Sharp R. Effect of dietary supplements on lean mass and strength gains with resistance exercise: a meta-analysis. Scand J Med Sci Sports. 2003;13:272.
8. Nissen SL, Sharp RL. Effect of dietary supplements on lean mass and strength gains with resistance exercise: a meta-analysis. J Appl Physiol. 2003;94:651-9.
9. Storer TW, Magliano L, Woodhouse L, et al. Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. J Clin Endocrinol Metab. 2003;88(4)1478-1485.
10. Zhou ZH, Liu JH, Jin YL, He P, Zhao PL, Wang XM. [Effects of different loading exercises on endogenous sex hormones and their metabolites]. Hunan Yi Ke Da Xue Xue Bao. 2000;25:23-6.
11. Bhasin S, Woodhouse L, Casaburi R, et al. Testosterone dose-response relationships in healthy young men. Am J Physiol Endocrinol Metab. 2001;281:E1172-81.
12. Porth CM. Hormonal control of male reproductive function. In: Pathophysiology: Concepts of Altered Health States. 5th ed. Philadelphia, Pa: Lippincott; 2002: 959-963.
13. Guyton AC, Hall JE. Chemistry of the sex hormones. In: Textbook of Medical Physiology.10th Ed. Philadelphia, Pa: W.B. Saunders Company; 2000: 933-934.
14. Jones ME, Simpson ER. Oestrogens in male reproduction. Baillieres Best Pract Res Clin Endocrinol Metab. 2000;14:505-16.
15. Muti P, Westerlind K, Wu T, et al. Urinary estrogen metabolites and prostate cancer: a case-control study in the United States. Cancer Causes Control. 2002;13:947-55.
16. Yoo HJ, Sepkovic DW, Bradlow HL, Yu GP, Sirilian HV, Schantz SP. Estrogen metabolism as a risk factor for head and neck cancer. Otolaryngol Head Neck Surg. 2001;124:241-7.
17. Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996;150:259-65.
18. Day JM, Newman SP, Comninos A, et al. The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells. J Steroid Biochem Mol Biol. 2003;84:317-25.
19. Maran A, Zhang M, Kennedy AM, et al.. 2-methoxyestradiol induces interferon gene expression and apoptosis in osteosarcoma cells. Bone. 2002;30:393-8.
20. Djavaheri-Mergny M, Wietzerbin J, Besancon F. 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. Oncogene. 2003;22:2558-67.
21. Ghosh R, Ott AM, Seetharam D, Slaga TJ, Kumar AP. Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: therapeutic implications? Melanoma Res. 2003;13:119-27.
22. Tinley TL, Leal RM, Randall-Hlubek DA et al. Novel 2-methoxyestradiol analogues with antitumor activity. Cancer Res. 2003;63:1538-49.
23. Thibodeau PA, Kachadourian R, Lemay R, Bisson M, Day BJ, Paquette B. In vitro pro- and antioxidant properties of estrogens. J Steroid Biochem Mol Biol. 2002;81:227-36.
24. Lippert C, Seeger H, Mueck AO, Lippert TH. The effects of A-ring and D-ring metabolites of estradiol on the proliferation of vascular endothelial cells. Life Sci. 2000;67:1653-8.
25. Newfield L, Bradlow HL, Sepkovic DW, Auborn K. Estrogen metabolism and the malignant potential of human papillomavirus immortalized keratinocytes. Proc Soc Exp Biol Med. 1998;217:322-6.
26. Service RF. New role for estrogen in cancer? Science. 1998;279(5357):1631-1633.
27. Zeligs MA. Safer estrogen with phytonutrition. Towns Lett. 1999;189:83-88.
28. Ho GH. Urinary 2/16 alpha-hydroxyestrone ratio: correlation with serum insulin-like growth factor binding protein-3 and a potential biomarker of breast cancer risk. Ann Acad Med Singapore 1998; 27:294-299.
29. Sepkovic DW. Estrogen metabolite ratios and risk assessment of hormone related cancers: assay validation and prediction of cervical cancer risk. Ann NY Acad Sci. 1995;768:312-316.
30. Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A. 1997;94:10367-72.
31. Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev. 2001;10:949-954.
32. Nachshon-Kedmi M, Yannai S, Haj A, Fares FA. Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol. 2003;41:745-52.
33. Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem. 2003;278:21136-45.
34. Carter TH, Liu K, Ralph W Jr, et al. Diindolylmethane alters gene expression in human keratinocytes in vitro. J Nutr. 2002;132:3314-24.
35. Jellinck PH, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ, Bradlow HL. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem Pharmacol. 1993;45:1129-36.

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