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What makes up joints, anyway?

Technically, even our skulls – the parts that don’t move – were once considered “joints.” But, for our purposes, joints are places our bodies move and connect.
Joints are formed by flexible connective tissues that hold bones together and allow range of movement. The ends of joints are covered with cartilage that protects the bones by reducing friction and absorbing shock when the bones move. (Yep – same as the yucky stuff you’ll notice when you’re eating chicken or turkey legs.)
The joint cavity is filled with a fluid that lubricates and protects the joint while providing oxygen and nutrients and removing wastes. Ligaments help to reinforce joints and add stability.
In the body, glucosamine is a main ingredient of the fluids and cushioning tissues that surround our joints. Glucosamine sulfate is simply a clinically studied form of glucosamine used in supplements, including GS-500™ dietary supplements.
To date, more than 20 clinical studies using glucosamine sulfate have been reported, with nearly 3,000 patients receiving either glucosamine sulfate or placebo. These studies show a favorable response to glucosamine sulfate vs. placebo in supporting healthy joint function.†
In fact, in one randomized, placebo-controlled trial with 202 patients, those who received glucosamine sulfate for three years showed greater knee health than those who took the placebo.† Those taking glucosamine sulfate had a healthier joint structure compared to those on placebo, as well as having joint function improve by 20-25 percent.†
You’ve probably seen glucosamine in different forms, including glucosamine sulfate and glucosamine hydrochloride. We selected glucosamine sulfate because of its high absorption and because the majority of successful clinical trials have used glucosamine sulfate rather than glucosamine hydrochloride. We simply consider it the preferred form.
Published November 15, 2011
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